Genes and Environment in the Risk of Early Age-Related Macular Degeneration: A Population-based Case-Control Study

本研究将汇集三个基于人群的老年人队列的数据，以获得大样本量，以调查基因和环境因素对年龄相关性黄斑变性（AMD）风险的相互作用。该研究将深入了解AMD的发病机制，并为AMD易感基因患者提供潜在的预防方法。这些可能最终减轻这种致盲疾病的负担。

This study will pool data from three well-conducted population-based cohorts of older persons to gain a large sample size in order to investigate the interplay of genes and environmental factors on the risk of age-related macular degeneration (AMD). The study will give insights into AMD pathogenesis, and enable potential targeting of people with AMD susceptibility genes for preventive approaches. These could ultimately reduce the burden of this blinding condition.