Development of remote quantum sensing using photonic technologies

在利兹大学，我们正在研究基于光的非侵入性技术来测量身体的生命参数。这项技术的核心依赖于自主开发的荧光材料平台，该平台通过使用短脉冲(飞秒)和高功率激光产生的等离子体对玻璃材料进行表面工程。一般的想法是用这种薄的功能表面在玻璃上产生的荧光照射皮肤，在低功率激光激励下，与血液中的生物分子和间质液体相互作用，提供光学响应。信号的变化提供了正在研究的生物标记物的分子特定浓度信息。作为生物传感器开发的第一步，这项技术已经被研究用于糖尿病患者的非侵入性血糖检测，以提供比目前的针头和基于血液的测量更快、更方便的替代方案，同时患者更舒适(没有疼痛)。然而，该设备的性能可以进一步改进并应用于其他场景，并且需要优化传感器材料的设计和制造。光学传感方面的挑战需要从工程和量子光学两个方面进行评估。该项目的具体目标：开发改进的量子理论以实现更好的传感设计一种新的实验设备来测试预测增强灵敏度和选择性的量子光学模型，优化改性玻璃层以实现非侵入性传感器性能，特别是计划使用二阶光子关联函数的测量来获得更好的生物传感器性能。建立适用于临床前和临床研究的传感设备原型规范

At the University of Leeds, we are investigating light based non-invasive techniques to measure the body vital parameters. The heart of this technique relies on an indigenously developed fluorescent material platform by the surface engineering of glass materials using a short pulse (femtosecond, fs) and high power laser produced plasma. The general idea is to shine the skin with fluorescence light produced by this thin functional surface on glass, under low power laser excitation, interacts with biomolecules in blood and interstitial fluid providing optical response. The variation in the signal provides molecule specific concentration information of the biomarker under investigation. As a first step in the development of the biosensor, the technology has been investigated for non-invasive glucose sensing for patients with diabetes to provide a faster, and convenient alternative at an increased patient comfort (no pain) relative to the current needle and blood-based measurements. However, the performance of the device can be further improved and applied to other scenarios and requires optimisation of the design and fabrication of sensor materials. The challenges in optical sensing need to be evaluated both from engineering and quantum optics aspects. Specific aims of the project: Develop modified quantum theories for better sensing Design a new experimental apparatus to test the quantum optical models which predict enhanced sensitivity and selectivity Optimise the modified glass layer for non-invasive sensor performances especially plan to use measurements of second-order photon correlation functions to obtain better biosensor performance. Establish specifications for the prototyping of sensing device suitable for preclinical and clinical investigations