Microbiological Characterisations of Dental Implants with Anti-infective and Photo-active Coating

本研究将着重于钛合金标准牙种植体的工程化抗感染和光活性涂层。抗感染/光敏涂层将使用氟磷灰石矿物设计。将使用旋涂和激光烧结进行涂覆。将使用硬度测量、FTIR、拉曼、UV-可见光、光致发光、血氧测量（使用氧合血红蛋白和脱氧血红蛋白的表征）来表征植入物的特性。将在成骨细胞、内皮细胞培养物中测试涂层植入物，并与厌氧/需氧细菌共培养，以原位鉴定活性蛋白。将使用X射线衍射、TEM/SEM和激光共聚焦显微镜进行材料表征。项目培训还将包括撰写专业标准的报告，并在小组中进行演示，领导项目。

The research will focus on engineering anti-infective and photoactive coating of standard dental implants, which are made from Ti-alloys. The anti-infective/photoactive coatings will be designed using fluorapatite minerals. Coating will be carried out using spin coating and laser sintering. The properties of implants will be characterised using hardness measurements, FTIR, Raman, UV-Visible, Photoluminescence, oximetric measurements using the characterisations of oxyhaemoglobin and deoxy-haemoglobin. The coated implants will be tested in osteoblast, endothelial cell cultures and also co-cultured with anaerobic/aerobic bacteria for the identification active proteins in situ. The materials characterisations will be carried out using X-ray diffraction, TEM/SEM, and laser confocal microscopy. The project training will also include writing reports of professional standards, and giving presentations in the group, leading the project.