Enhancing Patient-Oriented Research in Acute Lung Injury

描述（由申请人提供）：急性呼吸窘迫综合征（ARDS）是一种常见的、毁灭性的急性肺损伤，每年影响近20万美国人。目前，对这些危重病人没有药物治疗，死亡率仍然高达30-50%，令人无法接受。目前很少有研究人员开展高质量的以患者为导向的研究，这些研究涉及已经发生ARDS或有患该综合征风险的患者。我对ARDS的兴趣始于我的研究期间。我的导师是波莉·帕森斯博士在科罗拉多大学ARDS SCOR基金的支持下。在获得奖学金后，我继续在埃默里大学进行有关ARDS的临床、转化和流行病学研究，并从1996年开始获得校外资助。我的主要研究是检查酒精滥用增加ARDS发展易感性的机制。我还扩大了我对ARDS的兴趣，包括ARDS患者急性神经肌肉功能障碍的研究，以及使用国家数据库对ARDS或败血症患者进行流行病学研究。在此期间，我有幸指导了20名初级研究人员进行有关ARDS的以患者为导向的研究。这些受训者中的大多数仍留在学术医学领域，并获得独立的研究经费。基于我之前作为研究导师的成功经验，今年7月，我被重新招回科罗拉多大学，成为重症监护部门的负责人。招聘我的主要原因是与该科许多受人尊敬的基础科学研究人员建立新的合作项目，并指导对以患者为导向的急性肺损伤研究感兴趣的医学生、医务人员和初级教师。作为院长和医学部主席，我的最终任务是在急性肺损伤领域建立一个以患者为导向的研究项目。在这个奖项的支持下，我将能够成为与急性肺损伤相关的转化、临床和流行病学研究的领导者，成为肺和重症医学临床和转化研究发展的领导者，并培养下一代内科科学家。（摘要结束）

DESCRIPTION (provided by applicant): The acute respiratory distress syndrome (ARDS) is a common and devastating form of acute lung injury that affects nearly 200,000 Americans each year. Presently, there are no medical therapies available for these critically ill patients, and the mortality remains unacceptably high at 30-50%. There are a paucity of investigators who perform high quality patient oriented research involving patients who have developed ARDS or are at risk for this syndrome. My interest in ARDS began during my fellowship. I was mentored by Dr. Polly Parsons with the support of the ARDS SCOR grant at the University of Colorado. After my fellowship, I continued to conduct clinical, translational, and epidemiological research concering ARDS at Emory University, and have received extramural funding for my work since 1996. My primary research studies examine the mechanisms by which alcohol abuse increases susceptibility to the development of ARDS. I have also expanded my interests in ARDS to include studies of acute neuromuscular dysfunction in ARDS patients, and epidemiological studies of patients with ARDS or sepsis using national databases. During this time, I was fortunate to have mentored 20 junior investigators in patient oriented research concerning ARDS. The majority of these trainees have remained in academic medicine and obtained independent funding for their research. Based on my prior success as a research mentor, I was recruited back to the University of Colorado to become the Head of Critical Care this July. The primary reason for my recruitment was to establish new collaborative projects with the many esteemed basic science researchers in the division and to mentor medical students, housestaff, and junior faculty who have an interest in patient oriented acute lung injury research. My ultimate charge from the Dean and Chairman of the Department of Medicine is to build a patient-oriented research program in the area of acute lung injury. With the support of this award, I will be able to establish myself as a leader in translational, clinical, and epidemiological research related to acute lung injury, to become a leader in the development of clinical and translational research in pulmonary and critical care medicine, and to train the next generation of physician-scientists. (End of Abstract)