PACIFIC NORTHWEST PROSTATE CANCER SPORE

描述(由申请人提供)： 太平洋西北前列腺癌孢子是由四个在前列腺癌研究和职业发展方面拥有强大计划的机构共同努力的结果：1)弗雷德·哈钦森癌症研究中心(FHCRC)；2)华盛顿大学(UW)及其附属机构；3)系统生物学研究所(ISB)；4)不列颠哥伦比亚大学和温哥华总医院的前列腺中心和研究所。这三家总部位于西雅图和不列颠哥伦比亚省(BC)的机构拥有大量致力于前列腺癌(CAP)研究的研究人员和实验室。在这一环境中，已经存在大量的技术基础设施(例如基因组学)，强大的多学科专业知识(例如分子生物学、生物化学、流行病学、遗传学、医学和放射肿瘤学、泌尿学)，以及广泛的资源(例如血清、DNA和组织库、CAP动物模型设施、CAP基因组阵列和CAP临床试验组织)。所有四个机构都已经并正在为翻译上限研究项目增加资源，并致力于为这个孢子的目标贡献大量资源。孢子的目的不仅是执行所提出的研究项目，而且在更广泛的意义上，形成太平洋西北地区协同翻译帽研究的大型发展中的“马赛克”的“中心支撑件”。我们相信这些项目具有创新性和翻译性。项目1是一项以人群为基础的研究，评估特定的基因多态与CAP进展/死亡率的关系。项目2旨在描述播散性帽子细胞的分子变化(核型、转录本)，以影响患者的临床治疗作为诊断和预后指标。项目3将确定从雄激素依赖型向雄激素非依赖型CAP转变的关键决定因素，并将在特征良好的临床前模型和临床试验中验证这些发现。项目4旨在扩大我们在CAP基因组学方面已经广泛的工作，并将确定肿瘤基因表达谱是否可以预测疾病过程和对细胞毒化疗的反应。我们提出了五个核心来支持这些项目(管理、标本/组织、生物统计学、信息学和基因表达以及临床研究)。我们提出的职业发展和试点项目计划将大大美化和加强我们前列腺癌研究的翻译方向，并为新的研究人员扩大机会。

DESCRIPTION (provided by applicant): The Pacific Northwest Prostate Cancer SPORE is a coordinated effort of four institutions with strong programs in prostate cancer research and career development: 1) the Fred Hutchinson Cancer Research Center (FHCRC); 2) the University of Washington (UW) and its affiliated institutions; 3) the Institute for Systems Biology (ISB); and 4) the University of British Columbia and the Prostate Center & Institute of Vancouver General Hospital. These three Seattle-based and the British Columbia (BC)-based institutions have a large number of investigators and laboratories dedicated to prostate cancer (CAP) research. Within this milieu, there already exists substantial technical infrastructure (e.g., genomics), strong multidisciplinary expertise (e.g., molecular biology, biochemistry, epidemiology, genetics, medical & radiation oncology, urology), and extensive resources (e.g., serum, DNA & tissue banks, CaP animal model facilities, CaP genomic arrays, and a CaP clinical trials organization). All four institutions have, and are in the process of generating, increasing resources for programs in translational CaP research and are committed to contributing significant resources toward the goals of this SPORE. The purpose of the SPORE is not only to perform the research projects proposed, but in a larger sense to form the "central supporting piece" to a large developing "mosaic" of coordinated translational CaP research in the Pacific Northwest. We believe the projects to be innovative and translational. Project 1 is a population-based study evaluating specific genetic polymorphisms in relation to CaP progression/mortality. Project 2 aims to characterize molecular alterations (karyotype, transcript) of disseminated CaP cells in the context of influencing the clinical management of patients as diagnostic and prognostic indicators. Project 3 will identify critical determinants of the transition from androgen-dependent to androgen-independent CaP, and will validate these findings in well-characterized pre-clinical models and clinical trials. Project 4 seeks to expand our already extensive work on the genomics of CaP and will determine if tumor gene expression profiles can predict the course of disease and response to cytotoxic chemotherapy. We have proposed five Cores in support of these projects (Administration, Specimen/Tissue, Biostatistics, Informatics & Gene Expression, and Clinical Research). The Career Development and Pilot Project Programs we propose will significantly embellish and strengthen the translational orientation of our prostate cancer research and expand opportunities for new investigators.