Genetic and evironmenal risk factors for melanoma: translation into behavioural change

GenoMEL，以前称为黑色素瘤遗传学联盟，专注于家族性高转移率黑色素瘤基因的鉴定。联合研究方案在查明易感基因和为基因-环境相互作用研究联合收集数据方面非常成功。为了继续发挥其积极作用，GenoMEL希望建立一个多学科的欧洲平台，旨在：1.开发共享资源和活动2.识别新的易感基因并了解这些基因在肿瘤中的作用3.已知易感基因基因型-表型互作和基因-环境互作研究4.调查欧洲人对黑色素瘤风险态度，并将风险认知转化为行为改变5.通过创建一个可广泛访问的基于网络的内容管理系统（CMS）来传播卓越，以解决预防、早期检测、黑色素瘤诊断和遗传咨询问题。通过GenoMEL的联合执行研究，各团体将支持该网络的目标，即保持卓越的研究，增加机构整合，并在欧洲和其他国家建立一个持久的转化黑色素瘤遗传学研究结构。欧洲一体化将加强对话，传播专门知识和资源，提供培训，并允许科学家在欧洲内部流动。其目的是通过增加新的合作伙伴来保持网络的开放性和动态性，特别是在东欧，如果预期的财富增加导致更高水平的阳光照射，那么在不久的将来黑色素瘤发病率可能会急剧上升。将有四个新的欧洲团体和来自澳大利亚、美国和以色列的其他团体参加，以利用这些团体之间的纬度（阳光照射）差异。

GenoMEL, formerly known as the Melanoma Genetics Consortium, has focused on the identification of familial high penetrance melanoma genes. The joint programme of research has been very successful in the identification of susceptibility genes and developing joint data collection for gene-environment interaction studies. In order to continue its proactive role, GenoMEL wishes to develop a multidisciplinary European platform, directed towards: 1. developing shared resources and activities 2. identification of new susceptibility genes and understanding the role of these genes in tumours 3. investigation of genotype-phenotype interaction and gene-environment interaction for known susceptibility genes 4. investigation of attitudes to risk of melanoma in Europe, and translation of that risk perception into behavioural change 5. spreading excellence by creating a widely accessible web-based content management system (CMS) to address prevention, early detection, dealing with the diagnosis of melanoma and genetic counselling. Through GenoMEL's jointly executed research, groups will support the network's goal to maintain excellence in research, increase institutional integration and create an enduring structure of translational melanoma genetics research in Europe and other countries. European integration will enhance dialogue, disseminate expertise and resources, provide training and allow mobility of scientists within Europe. It is aimed to keep the network open and dynamic by adding new partners, especially in Eastern Europe where melanoma incidence rates may rise most precipitously in the near future, if the expected increase in wealth results in greater levels of sun exposure. There will be participation from four new European groups and others from Australia, the USA and Israel to capitalize on latitudinal (sun exposure) differences between these groups.