Next Generation Bio-Orthogonal Ynamine Reagents for the Preparation of Antibody-Drug Conjugates

精确功能化的小分子先导化合物的制备是药物发现管道的重要组成部分。然而，离散官能化生物缀合物的伴随发展尚未发展到同等水平的复杂性。本研究的目的是开发一种新的生物正交标记方法，用于制备抗体-寡核苷酸生物缀合物。本研究项目将涉及合成化学、化学生物探针设计和质谱组学技术。

The preparation of precisely functionalised small molecule lead compounds is essential part of the drug discovery pipeline. However, concomitant development of discretely functionalized bioconjugates have not developed to an equivalent level of sophistication. The objective of this studentship is to develop a new bio-orthogonal tagging methodology for the preparation of antibody-oligonucleotide bioconjugates. This studentship will involve a blend of synthetic chemistry, chemical biological probe design, and mass spectrometric -omics techniques.