FASEB Summer Conference on: The Biology of Calpains in Health and Disease

描述(由申请者提供)：FASE B计划于2007年7月举办一次夏季会议，题为“钙痛在健康和疾病中的生物学”。这是第四次这样的会议，重点是脚踝疼痛，会议将在科罗拉多州的斯诺马斯举行。目前正在向三个不同的NIH研究所申请资金，这些研究所包括NIAMS作为主要机构，NHLBI和NIA作为共同赞助商。从这些研究所获得的资金将为会议提供部分支持。今年的会议将有两个主要重点：1)了解钙蛋白酶的生化特性；2)了解钙蛋白酶在各种疾病过程中的作用。会议计划举行八场刺激会议，内容包括1)钙蛋白结构和结构-功能关系，2)钙蛋白的生物化学，3)癌症、细胞凋亡和细胞周期中的钙蛋白，3)钙蛋白和横纹肌疾病，4)钙蛋白和神经变性，5)细胞运动、信号和整合素，6)钙蛋白与衰老和疾病的调节，7)心肌和缺血中的钙蛋白，8)动物科学中的钙蛋白。Ernesto Carafoli博士将作为主旨发言人，他将在会议开幕当天介绍他在细胞钙调节方面的工作。卡拉福利博士是钙调节方面的世界专家，钙调节对钙激活很重要。一次关于钙调蛋白生物学的会议与美国国立卫生研究院高度相关，因为钙调蛋白既涉及正常过程，也涉及病理过程。看家钙蛋白酶的活性对所有组织中正常的蛋白质周转和细胞骨架和膜蛋白的加工都是重要的。钙蛋白酶3和10的突变与衰弱的疾病(肌肉营养不良和糖尿病)有关。自上次关于钙蛋白的会议以来，已经过去了三年，在基因组学、结构激活和在疾病中的作用方面取得了实质性的进展。拟议的方案将提供一个论坛，通过这个论坛可以保持这一领域的势头。

DESCRIPTION (provided by applicant): A FASEB summer conference is planned for July 2007 entitled "Biology of Calpains in Health and Disease". This is the fourth such meeting focusing on calpains and it will be held in Snowmass, Colorado. Funds are being requested from three different NIH institutes that include NIAMS as the primary and NHLBI and NIA as co-sponsors. Funds obtained from these institutes will provide partial support for the meeting. The meeting this year will have two main emphases; 1) understanding the biochemical properties of calpains and 2) understanding the role of calpains in various disease processes. Eight stimulating sessions are planned for the meeting including 1) Calpain Structure and Structure-Function Relationships, 2) Biochemistry of Calpains, 3) Calpains in Cancer, Apoptosis and the Cell Cycle, 3) Calpains and Striated Muscle Disease, 4) Calpains and Neurodegeneration, 5) Cell motility, Signaling and Integrins, 6) Calpains in the Modulation of Aging and Disease, 7) Calpains in Cardiac Muscle and Ischemia and 8) Calpains in Animal Science. Dr. Ernesto Carafoli will be the keynote speaker and he will present his work on calcium regulation in cells on the opening day of the meeting. Dr. Carafoli is a world expert in calcium regulation, an issue that is important for calpain activation. A meeting on the biology of the calpains is highly-relevant to the NIH because calpains are involved in both normal and pathological processes. The activities of the house-keeping calpains are important for normal protein turnover and processing of cytoskeletal and membrane proteins in all tissues. Mutations in calpains 3 and 10 have associations with debilitating diseases (muscular dystrophy and diabetes). Three years have passed since the last meeting on calpain and substantial progress on the genomics, structure activation and roles in disease have been made. The proposed program will provide the forum by which the momentum in this field may be maintained.