CROSS-NATIONAL STUDIES OF DRUG INVOLVEMENT: WMH2000

描述（由申请人提供）：该提案寻求为期五年的R 01奖支持，用于对已经收集的药物依赖流行病学数据进行跨国比较分析，药物参与导致药物依赖的阶段，以及药物依赖的后遗症，包括缓解，恢复，治疗和疑似不良后果（例如，精神障碍，以及对学校、工作和家庭生活中的社会适应的影响）。作为世界精神卫生调查倡议的一部分，目前正在收集有待分析的一般人口流行病学调查数据，目前有28个国家参加，其中16个国家的家庭居民样本具有全国代表性，12个国家的样本具有区域代表性。拟议中的NIDA支持的数据分析和科学写作研究小组由Jim Anthony教授（约翰霍普金斯大学）和罗恩凯斯勒教授（哈佛大学）领导。协调工作，在01年期间，哈佛团队的主要职责是主数据文件的创建和文件编制职责，包括抽样框架和程序的文件编制，抽样重量等，霍普金斯团队专注于为面向NIDA的药物依赖性分析创建构造变量，并收集辅助信息要素，这些信息要素将有助于描述每个参与国药物参与的国家层面背景（例如，关于酒精、烟草、非法药物和处方或非处方药物的信息;当地吸入剂药物的可用性）。五年分析和科学写作计划将在一组三个业务目标和五个主题目标的指导下，提供对药物使用和药物依赖问题的国际比较流行病学的更好看法，其中每一个都对应于关于药物参与和药物依赖的流行病学研究的概念模型中的五个主要rubics。在这项跨国比较研究中要回答的主要研究问题是：（1）在所研究的人群中，有多少人受到影响（例如，药物依赖）。(2)在这些人群中，哪里最有可能发现受影响的病例？(3)是什么原因导致一些人成为案件，而另一些人没有成为案件？(4)什么是驱动药物依赖的发病机制和病因学及其以精神障碍和社会适应形式的后果的因果机制，以及（5）我们可以做些什么来预防和控制药物依赖（例如，通过增加治疗/未治疗病例的比例，并通过初级保健外展）？

DESCRIPTION (provided by applicant): This proposal seeks five years of R01 award support for cross-national comparative analyses of already gathered data on drug dependence epidemiology, the stages of drug involvement leading up to drug dependence, and sequelae of drug dependence, including remission, recovery, treatment, and suspected adverse consequences (e.g., psychiatric disturbances, and effects on social adaptation in school, work, and family life). The general population epidemiological survey data to be analyzed now are being gathered as part of the World Mental Health survey initiative, with currently 28 participating countries, including 16 countries with nationally representative samples of household residents and 12 countries with regionally representative samples. The proposed NIDA-supported research team for data analysis and scientific writing is led by Professors Jim Anthony (Johns Hopkins University) and Professor Ron Kessler (Harvard University). Working in coordination, during Year 01, the primary responsibility of the Harvard team is master data file creation and documentation responsibilities, including documentation of sampling frames and procedures, sampling weights, etc., with the Hopkins team focused upon creation of constructed variables for NIDA-oriented drug dependence analyses and assembly of ancillary elements of information that will help describe the country-level context of drug involvement in each of the participating countries (e.g., information about alcohol, tobacco, illegal drug, and medicinal drug availability by prescription or over the counter; availability of local inhalant drugs).The five year analysis and scientific writing plan will provide an enhanced view of the international comparative epidemiology of drug use and drug dependence problems, guided by a set of three operational aims and five subject-matter aims, each of which corresponds with the five main rubics in a conceptual model for epidemiologieal research on drug involvement and drug dependence. The main research questions to be answered in this cross-national and comparative study are: (1) Within the populations under study, how many are affected (e.g., as cases of drug dependence)? (2) Within these populations, where are the affected cases most likely to be found? (3) What accounts for some individuals to become cases while others do not become cases? (4) What are the causal mechanisms that drive the pathogenesis and etiology of drug dependence and its consequences in the form of psychiatric disturbances and social adaptation, and (5) What might we do to prevent and control drug dependence (e.g., by increasing the ratio of treated/untreated cases, and through primary care outreach)?