Gammacell-40 Exactor Research Irradiator

描述(由申请者提供)：申请资金用于MDS Nordian Inc.Gammacell-40自给式低剂量率研究动物(啮齿动物)照射器，以支持正在进行的由NIH资助的个人发起的研究计划，该研究计划位于宾夕法尼亚大学兽医学院校园内一座最近建成的研究大楼(Hill Pavilion)内。10个核心实验室构成了所要求的仪器的主要用户名单。每个实验室都将在希尔展馆或毗邻的宾夕法尼亚兽医学校的研究实验室，所有这些实验室都将安置他们的小鼠，并在希尔展馆的动物设施中进行正在进行的实验，需要进行全动物辐射和延长受辐射动物的维护时间。这些核心实验室将构成兽医学院使用辐照仪的大部分(70%)。有一组额外的兽医学院教员将不经常(&lt；5%)使用这种仪器。此外，由于希尔的隔膜将与医学院共享，宾夕法尼亚大学医学院的NIH资助教职员工将占用希尔展馆新动物设施的一部分(25%)。之所以需要这种仪器，是因为核心用户群体的动物所在的新动物设施是一个封闭式设施，被带到其他建筑物进行照射的动物不能返回到调查员设计的区域。因此，不可能进行需要在照射后保持动物一天以上的长期实验，或者需要比较照射和非照射的试验组。正如项目描述中详细描述的那样，这些包括辐射、自动重建模型、骨髓嵌合体、诱导免疫缺陷等。宾夕法尼亚大学兽医学院已经作出重大财政承诺，通过建造放置辐照器的房间来支持该仪器的采购。此外，学校已承诺为正在进行的维修合同提供资金，以维护和维修仪器，并将为一名监督员提供工资支持。该大学将为安全提供支持。在间隔山展馆安装Gammacell-40将使阐明对病原体和肿瘤的免疫反应以及干细胞研究成为可能。每一项都将促进我们对人类疾病的理解。

DESCRIPTION (provided by applicant): Funds are requested for a MDS Nordian Inc. Gammacell-40 Exactor Self-contained Low Dose Rate Research animal (rodent) irradiator to support the ongoing NIH-funded individual-initiated research programs in a new state of the art animal facility located within a recently erected research building (Hill Pavilion) on the campus of the University of Pennsylvania School of Veterinary Medicine. Ten core laboratories comprise the list of the major users of the requested instrument. Each will have laboratories in either the Hill Pavilion or the adjacent research laboratories at the Penn Vet School and all of them will house their mice and perform ongoing experiments requiring whole animal irradiation and extended maintenance of irradiated animals in ongoing experiments in the animal facility in the Hill Pavilion. These core laboratories will constitute the majority (>70%) of the usage of the irradiator by the School of Veterinary Medicine. There is a group of additional Veterinary School faculty that will utilize this instrument on an infrequent (<5%) basis. In addition, since the vivarium in Hill will be shared with the School of Medicine, there will be substantial usage by NIH-funded faculty from University of Pennsylvania School of Medicine who will occupy part of the new animal facility in the Hill Pavilion (25%). A specific need for this instrument arises because the new animal facility in which the animals of the core user group are housed is a closed facility in which animals taken to other buildings for irradiation cannot be returned to the investigator's designed area. As a consequence, it is impossible to perform long-term experiments requiring maintaining the animals beyond a single day after irradiation, or that require comparison of irradiated and non-irradiated experimental groups. As detailed in the project descriptions, these include irradiated, auto-reconstituting models, bone marrow chimeras, induction of immunodeficiency, among others. The University of Pennsylvania School of Veterinary Medicine has already made a significant financial commitment to support the procurement of this instrument, by constructing the room in which the irradiator will be housed. In addition, the School has committed funds for the ongoing service contract to maintain and service the instrument, and will provide salary support for a supervisor. The University will provide support for security. The installation of the Gammacell-40 in the Hill Pavilion vivarium will make possible studies that will elucidate immune responses to pathogens and tumors, as well as studies of stem cells. Each of these will advance our understanding of human diseases.