Developing Drugs from Natural Product Scaffolds

我们希望从天然产品支架开始合成类似药物的实体，我们可以以克为单位获得。这将涉及化学合成，后期功能化，原子经济催化，机械化学，制备高效液相色谱，微波，流动化学的使用。学生将在行业标准实验室接受培训，学习平行合成和文库生成以及药物化学基础（通过授课和博士实验室项目），如生物同位体，构象限制，溶解基团的使用，在一个由几位具有行业经验的博士后化学家和生物学家组成的团队中工作。也有可能开发类似药物的实体，并了解内政部许可和GMP。作为培训计划的一部分，将有机会在工业合作伙伴的实验室度过一段时间（通常为3个月）。

We wish to synthesise druglike entities starting from a natural product scaffold that we can acquire in gram quantities. This will involve chemical synthesis, late-stage functionalisation, atom economical catalysis, mechanochemistry, use of preparative HPLC, microwaves, flow chemistry.The student will be trained in an industry-standard laboratory, learn about parallel synthesis and library generation and fundamentals of medicinal chemistry (through taught classes and, also, through the PhD laboratory project) such as bioisosteres, conformational restriction, use of solubilising groups, working in a team comprising several industrially-experience postdoctoral chemists and biologists. There is also a possibility to develop druglike entities and learn about Home Office Licensing and GMP.There will be an opportunity, as part of the training programme, to spend time (usually 3 months) in the industrial partner's laboratories.