Microevolution of Salmonella enterica serovar Typhimurium - molecular basis of emerging threats to human health

食源性细菌病原体的新菌株变体如何以及为什么会出现并取代已有的菌株？这个问题的答案对于干预细菌病原体沙门氏菌在牲畜和野生动物中的传播非常重要，因为它们是人类感染的宿主。学生将采用计算方法来识别新出现的沙门氏菌菌株和分子生物学，以了解与涌现相关的关键特征的微进化的后果。

How and why do new strain variants of foodborne bacterial pathogens emerge and replace pre-existing strains? The answer to this question is important to intervening in the spread of the bacterial pathogen Salmonella within livestock and wild animals that are reservoirs of infection in people. The student will employ computational approaches to identify newly emerging strains of Salmonella and molecular biology to understand the consequences of microevolution on key characteristics associated with emergence.