Classification and Epidemiology of Emotional Disorders

描述(由申请人提供)：这份修订后的研究科学家发展奖(K01)申请书概述了一个为期5年的培训计划，该计划将使候选人为专注于情绪障碍及其共病研究的独立研究生涯做好准备。应聘者的职业目标是研究情绪障碍和焦虑症之间以及与正常情绪之间的潜在界限，并利用这些知识来加强对情绪障碍的分类和评估。然而，虽然应聘者在焦虑症和Meehl的税法方面有很强的背景，但她还需要另外4个领域的技能来实现她的长期目标：(1)精通税法之外的分类研究的统计技术；(2)对情绪障碍的深入知识；(3)对症状数据以外的变量(即神经生物学、个性、遗传)的理解，这些变量对情绪障碍的分类非常重要；以及(4)精神流行病学的经验，这是传统上被招募来完善病因学系统的领域。这些知识差距将通过以下方式解决：(1)统计学、情绪障碍、神经生物学、个性和遗传流行病学方面的教学培训；(2)情绪障碍及其合并症方面的临床培训；(3)通过两个主要调查的研究学徒，进行精神流行病学培训，旨在为ICD-11和DSM-V的修订提供信息；以及(4)进行指导研究项目。该研究项目将结合结构和流行病学研究方法，目的是(I)描绘流行病学样本中6种常见的共生情绪和焦虑障碍的完整潜在结构，(Ii)根据关于潜在结构的信息评估修改诊断标准和阈值的流行病学后果，以及(Iii)检验利用关于潜在结构的信息分类的单纯和合并情绪障碍的流行病学相关性。该项目预计将为R01提案的制定提供信息，以支持对情绪焦虑共病的进一步研究，并完善候选人在这一领域进行富有成效的独立研究的能力。预计该项目还将产生与公共卫生有相当大相关性的结果，有可能导致更有效和有用的诊断评估，更好地发现需要服务的个人，以及更有效地预防和治疗精神痛苦。

DESCRIPTION (provided by applicant): This revised application for a Mentored Research Scientist Development Award (K01) outlines a 5-year training plan that will prepare the candidate for an independent research career focusing on the study of emotional disorders and their comorbidity. The candidate's career goal is to investigate the latent boundaries that separate the mood and anxiety disorders from one another and from normal emotions and to use this knowledge to enhance the classification and assessment of emotional disturbance. However, while the candidate has a strong background in the anxiety disorders and in Meehl's taxometric method, she requires skills in 4 additional areas to achieve her long-term goals: (1) proficiency in the statistical techniques of classification research beyond the taxometric method; (2) in-depth knowledge of the mood disorders; (3) understanding of variables beyond symptom data (i.e., neurobiological, personality, genetic) that are important for the classification of emotional disorders; and (4) experience with psychiatric epidemiology, the field traditionally enlisted to refine nosological systems. These gaps in knowledge will be addressed by: (1) didactic training in statistics, mood disorders, neurobiology, personality, and genetic epidemiology; (2) clinical training in emotional disorders and their comorbidity; (3) training in psychiatric epidemiology through research apprenticeships on two major surveys designed to inform revisions for ICD-11 and DSM-V; and (4) the conduct of a mentored research project. The research project will integrate the methods of structural and epidemiological research with the aims of (i) delineating the full latent structure of 6 commonly co-occurring mood and anxiety disorders in epidemiological samples, (ii) evaluating the epidemiological consequences of modifying diagnostic criteria and thresholds based on information about latent structure, and (iii) examining epidemiological correlates of pure and comorbid emotional disorders classified using information about their latent structure. This project is expected to inform the development of an R01 proposal to support further research into mood-anxiety comorbidity and to round out the candidate's ability to conduct productive, independent research in this area. The project is also expected to yield results with considerable relevance for public health, with the potential to lead to more valid and useful diagnostic assessments, better detection of individuals in need of services, and more effective prevention and treatment of emotional suffering.