Impacts of Air Pollution from Ultrafine Tire-Wear Particles on Cardiorespiratory Health

由于车辆发动机排放的减少，轮胎磨损在与交通相关的空气污染总量中的相对贡献正在增加[1]。然而，我们对超细轮胎颗粒对健康影响的了解仍然有限。轻型轮胎通常由来自原油的合成橡胶制成，而不是天然橡胶。这增加了轮胎的多环芳烃（PAH）成分，以及轮胎相关颗粒物（PM）的潜在心脏毒性[2]。对于这个博士项目，学生将与我们的工业合作伙伴，排放分析密切合作，排放分析是乘用车和商用车实际排放独立测试的全球领导者。在这里，学生将学习尖端的化学分析技术，并生成真实的轮胎磨损颗粒，用于他们的生物医学测试系统。在曼彻斯特大学，博士候选人将调查轮胎磨损空气污染对人类健康的影响，使用肺和心脏体外分析系统，分别关注每个系统以及肺和心脏系统之间的相互连接。为了将体外系统研究的结果与人类健康联系起来，该项目将以流行病学调查结束，该调查将调整当前PM污染和健康的暴露模型[4]，以包括轮胎磨损的PM。

Due to reduction in engine emissions from vehicles, the relative contribution of tire-wear in total traffic related air pollution is increasing [1]. However, our understanding of the health effects of ultrafine tire particles is still limited. Light-duty tires are typically made up of synthetic rubber, derived from crude oil, rather than natural rubber. This increases the polycyclic aromatic hydrocarbon (PAH) component of tires, and the potential cardiotoxicity of tire-related particulate matter (PM) [2]. For this PhD CASE project, the student will work closely with our Industrial Partner, Emissions Analytics [3] who is global leader in independent testing of realworld emissions for passenger and commercial vehicles. Here the student will learn cutting-edge chemical analytics techniques and generate real-life tire-wear particles for use in their biomedical test systems. At the University of Manchester, the PhD candidate will investigate the impact of air pollution from tire-wear on human health using lung and cardiac in vitro assay systems focussing on each system independently as well as the interconnectivity between lung and heart systems. To relate findings from the in vitro systems studies to human population health, the project will finish with an epidemiological investigation which adapts current exposure models of PM pollution and health [4] to include PM from tire-wear.