Lightweight Ambient Pressure & Temperature Oxygen Concentrator (LAPTOC)

描述(由申请人提供)：此二期项目的目标是为COPD患者提供负担得起且不显眼的便携式氧气供应。长期氧疗(LTOT)--持续氧气结合运动--显著提高了这些患者的存活率。开发一种不会干扰正常日常活动的安全电池供电设备将促进患者对治疗的依从性，并提高他们的生活质量。该研究项目支持NHLBI的使命，即指导与肺部疾病患者的治疗和康复相关的设备的开发研究。正在开发的便携式氧气浓缩器重量将不到1.5公斤，但将在6小时内提供所需的2-3升/分钟(LPM)当量氧气流量。与现有便携式集中器相比，性能的显著提高将通过重新设计集中器架构来实现。三维原型将被用来制造能量存储、动力传输和惯性阻尼组件，这些组件共享功能，从而减少设备质量。作为SDGroup和其他地方正在开发的快速动力学空气分离吸附剂将使专有的快速循环、能量恢复设计的应用成为可能，该设计将能耗降低到15W/LPM输送的氧气。将开发自适应功率控制算法来协调传感器输入、患者数据和服务器功能。患者数据记录将集成到该设备中，使呼吸临床医生能够确认依从性并进行个性化治疗。慢性阻塞性肺疾病(COPD)在美国困扰着超过1250万人，是第四大死因。运动结合持续氧疗已被证明是治疗这种疾病的最有效的方法。该项目将开发一种极其紧凑、轻巧和安静的便携式氧气浓缩器，将提高患者的依从性，并改善需要长期氧疗(LTOT)的低氧血症COPD患者的生活质量。

DESCRIPTION (provided by applicant): The objective of this Phase II project is to provide an affordable and unobtrusive portable oxygen supply for COPD patients. Long term oxygen therapy (LTOT)-continuous oxygen combined with exercise-dramatically increases survival rates for these patients. Development of a safe battery operated device that does not interfere with normal daily activities will promote patient compliance with therapy and enhance their quality of life. This research project supports the NHLBI's mission to direct research in the development of devices related to the treatment and rehabilitation of patients suffering from lung disease. The portable oxygen concentrator under development will weigh less than 1.5 kg, yet will deliver the required 2-3 liters per minute (Lpm) equivalent oxygen flow for a period of 6 hours. This dramatic performance improvement over existing portable concentrators will be achieved by re-engineering the concentrator architecture. Three dimensional prototyping will be used to create energy storage, power transmission, and inertial damping components that share functionalities and thus reduce device mass. Fast kinetics air separation adsorbents being developed as SDGroup and elsewhere will enable the application of a proprietary rapid cycle, energy recuperative design that reduces power consumption to 15W/Lpm delivered oxygen. Adaptive power control algorithms will be developed to coordinate sensor input, patient data, and conserver functions. A patient data log will be integrated into the device, allowing the respiratory clinician to confirm compliance and personalize therapy. Chronic Obstructive Pulmonary Disease (COPD) afflicts over 12.5 million people in US and is the fourth leading cause of death. Exercise combined with continuous oxygen therapy has been shown to be the most effective treatment for this disease. This project will develop an extremely compact, lightweight and quiet portable oxygen concentrator that will augment patient compliance and improve quality of life for hypoxemic COPD patients requiring long term oxygen therapy (LTOT).