TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICS

描述（申请人提供）： 这是一份申请，要求支持继续开展1994年启动的培训方案，该方案致力于严格培训：（1）完成了风湿病学或骨科学科临床培训的积极性很高的医生;（2）选择获得博士学位的医生。（3）最近毕业的博士;致力于进行适用于流变学或骨科疾病的研究;及（4）希望从事人类临床研究的流变学家。该计划提供密切监督的密集实验室经验，强调分子生物学，遗传学，细胞生物学和生物化学的最先进方法的应用，以调查影响结缔组织和肌肉骨骼系统的疾病的病因和发病机制。该计划还提供了严格的培训，在人类临床调查研究的行为。该培训方案的主要优点是：（1）采用综合和多学科方法研究影响大部分人口的具有重大公共卫生和社会经济重要性的疾病;（2）高生产力和有成就的培训师骨干，（三）教师的专业知识和研究兴趣的多样性及其对最先进分子生物学方法的应用对各种风湿性和肌肉骨骼疾病的研究;（4）教师对医生科学家和博士的培训的长期承诺。的;和（5）最近在我们的机构建立了一个NIH支持的人类临床研究课程。该培训计划将我们机构以前正在进行的各种培训活动整合为一个统一的计划，该计划高度关注风湿和肌肉骨骼疾病的病因和发病机制的研究，以及获得在风湿和肌肉骨骼疾病中进行人类临床研究的培训和技能。所提供的培训机会具有统一的目标，即为学员准备应用分子生物学，遗传学，细胞生物学，生物化学和人类临床研究的最先进方法来研究影响肌肉骨骼系统的广泛疾病。在该计划完成后，学员将做好充分的准备，以获得学术任命，并追求职业生涯作为医生，科学家，临床研究者或博士。有能力在风湿病学和骨科相关领域建立独立的研究项目。

DESCRIPTION(Provided by Applicant): This is an application requesting support to continue a Training Program initiated in 1994 devoted to the rigorous training of: (1) highly motivated physicians who have completed their clinical training in the disciplines of Rheumatology or Orthopedics; (2) physicians who have chosen to obtain a Ph.D. degree during their training in Orthopedics; (3) recently graduated Ph.D.'s committed to conduct research applicable to Rheumatology or Orthopedic diseases; and (4) Rheumatologists wishing to pursue a career in Human Clinical Investigation. The program provides closely supervised intensive laboratory experience emphasizing the application of state of the art methods of Molecular Biology, Genetics, Cell Biology and Biochemistry towards the investigation of the etiology and pathogenesis of diseases affecting the connective tissues and the musculoskeletal system. The program also provides rigorous training in the conduct of human clinical investigation studies. The major strengths of this Training Program are: (1) the comprehensive and multidisciplinary approach to the study of disorders of great public health and socioeconomic importance which affect a large segment of the population; (2) the cadre of highly productive and accomplished trainors, (3) the diverse nature of the expertise and research interests of the faculty and their application of the most advanced molecular biological approaches to the study of various rheumatic and musculoskeletal diseases; (4) the long-term commitment of the faculty to the training of Physician Scientists and Ph.D.'s; and (5) the recent establishment at our institution of an NIH-supported Human Clinical Investigation Curriculum. The Training Program consolidates various training activities previously ongoing at our Institution into a unified program which is highly focused on the study of the etiology and pathogenesis of rheumatic and musculoskeletal diseases and on the acquisition of training and skills for the conduct of Human Clinical Investigation in the rheumatic and musculoskeletal diseases. The training opportunities offered have the unifying goal of preparing the trainees in the application of the most advanced methods of Molecular Biology, Genetics, Cell Biology, Biochemistry and Human Clinical Investigation to the study of a broad spectrum of diseases affecting the musculoskeletal system. At the completion of the program, the trainees will be well prepared to obtain academic appointments and to pursue careers as Physician-Scientists, Clinical Investigators or as Ph.D.'s capable of establishing independent research programs in areas relevant to Rheumatology and Orthopedics.