Amygdala and Prefrontal Control of the Rhinal Cortices

描述(申请人提供)：鼻皮质在陈述性记忆中起关键作用，并构成海马体和皮质之间冲动交通的主要通道。然而，生理数据表明，鼻皮质并不是一个被动的中继站；新皮质和内嗅觉的输入被传递的概率很低。这里描述的研究的目标是评估限制脉冲通过鼻皮质传播的抑制机制是否以及如何被解除。一种可能性是，这可能发生在情绪唤起的情况下，此时陈述性记忆通常会得到增强。杏仁核和内侧前额叶皮质都大量投射到鼻皮质，两者都与情绪促进记忆有关。麻醉猫体内的细胞外和细胞内记录将评估杏仁核和内侧前额叶皮质促进鼻皮质冲动传递的能力。

DESCRIPTION (provided by applicant): The rhinal cortices play a critical role in declarative memory and constitute the main route for impulse traffic between the hippocampus and cortex. However, physiological data suggests that the rhinal cortices are not a passive relay station; neocortical and entorhinal inputs are transmitted with a low probability. The goal of the research described here is to assess whether and how the inhibitory mechanisms that limit impulse propagation through the rhinal cortices are lifted. One possibility is that this could occur during emotionally arousing conditions, when declarative memory is generally enhanced. Both the amygdala and medial prefrontal cortex project heavily to the rhinal cortices, and both are implicated in the facilitation of memory by emotions. Both extracellular and intracellular recordings in vivo in anesthetized cats will assess the ability of the amygdala and medial prefrontal cortex to facilitate impulse transfer through the rhinal cortices.