IBD and Mucosal Inflammation, Immunology, and Microbiol*

整体中心描述(由申请人提供)： 这份申请是为芝加哥大学消化疾病研究核心中心(DDRCC)的竞争性续签申请。该中心的主要主题是研究炎症性肠病(IBD)和其他炎症性疾病以及胃肠道的过程。这个DDRCC已经成为一个高度多学科和合作的努力，涉及芝加哥大学生物科学部临床和基础科学系的72名研究人员(62名正式成员和10名准成员)。这个消化疾病研究中心的目标没有改变，其目的是：1)以支持性、综合性、协作性和多学科的方式促进与消化疾病相关的研究；2)提高现有消化疾病研究人员的基础研究能力；3)鼓励与消化疾病相关研究无关的研究人员有兴趣探索与这一重要研究领域相关的问题！4)制定和实施计划，培训和建立与消化疾病相关研究的年轻研究人员；5)促进将新的研究成果转移到临床领域；以及6)向其他专业和非专业人员通报消化疾病相关研究的成就、机会和进展。芝加哥大学的DDRCC有三个核心实验室(细胞生物学、分子生物学和生物化学以及分子和实验病理学)，以促进与消化系统疾病相关的研究、试点和可行性研究以及新的研究人员奖励计划，以促进年轻和成熟的研究人员参与与消化系统疾病相关的研究，以及一个行政核心，以监督中心的整体运作，确定科学方向，并促进与消化系统疾病研究相关的培训和教育。此外，行政核心增加了一个新的临床部分，以促进翻译研究。该构成部分将进一步促进临床和基础研究调查人员之间的互动。总而言之，这些目标和组成部分定义了芝加哥大学的DDRCC。

DESCRIPTION OF OVERALL CENTER (provided by applicant): This application is for the competitive renewal of the Digestive Diseases Research Core Center (DDRCC) at the University of Chicago. This Center's major theme is the study of Inflammatory Bowel Diseases (IBD) and other inflammatory diseases and processes of the GI tract. This DDRCC has become a highly multidisciplinary and cooperative endeavor involving 72 investigators (62 full members and 10 associate members) in the clinical and basic science departments of the Division of Biological Sciences at the University of Chicago. The aims of this DDRCC have not changed and are: 1) to foster digestive diseases related research in a supportive, integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of established digestive diseases investigators; 3) to encourage investigators not involved in digestive diseases-related research to become interested in pursuing problems related to this important area of investigation! 4) to develop and implement programs for training and establishment of young investigators in digestive diseases-related research; 5) to facilitate the transfer of new research findings to the clinical area; and 6) to inform others in both professional and lay settings of the accomplishments, opportunities and advances in digestive disease-related research. The DDRCC at the University of Chicago has three core laboratories (Cell Biology, Molecular Biology and Biochemistry, and Molecular and Experimental Pathology) to foster digestive diseases-related research, Pilot and Feasibility Studies and New Investigator Award programs to foster participation of younger and established investigators in research related to digestive diseases and an Administrative Core to oversee the operation of the Center as a whole, determine scientific direction, and promote training and education related to research in digestive diseases. In addition, a new Clinical Component to facilitate translational research has been added to the Administrative Core. The Component will further promote interactions between clinical and basic research investigators. Taken together, these objectives and components define the University of Chicago's DDRCC.