The Gulf Coast MBCCOP

描述（由申请人提供）：本申请的目的是为墨西哥湾沿岸中部地区的居民提供NCI支持的癌症治疗、预防和控制试验的持续访问。在过去的三年里，由于反复发生的自然灾害，墨西哥湾中部沿岸地区遭到了严重破坏，首先是飓风伊万（Ivan）摧毁了佛罗里达州彭萨科拉（Pensacola）的部分地区，然后是飓风卡特里娜（Katrina）摧毁了新奥尔良比洛克西/格尔夫波特（Gulfport）。重建工作远未完成，保健服务受到不利影响，在一些受灾地区仍然只有基本的医疗服务。因此，在国家层面维持更复杂的亚专科护理仍然是一个持续的挑战。尽管莫比尔在卡特里娜飓风之后也被宣布为联邦灾区，但它比西部的社区恢复得快得多。这使得MBCCOP相关活动得以持续，几乎没有停工时间，也为该地区流离失所的癌症患者提供了持续的随访和方案护理。甚至在风暴之前，能够提供NCI支持的合作小组研究的下一个最近的结构位于阿拉巴马州北部的伯明翰（260英里），佛罗里达州东部的盖恩斯维尔（390英里），以及洛杉矶新奥尔良的杜兰，LSD和Ochsner诊所（150英里）。随着路易斯安那州立大学完全失去了所有的医院和肿瘤服务，杜兰大学也失去了部分，奥克斯纳的能力也受到了影响。墨西哥湾沿岸MBCCOP累积了103名新患者，是该国前几年控制和预防试验的第五大累积CCOP，还有617名活跃患者在随访中。自卡特里娜飓风以来，墨西哥湾沿岸MBCCOP的比洛克西/格尔夫波特分支机构一直关闭。出于行政和竞争的原因，墨西哥湾沿岸MBCCOP受资助机构，流动医院医疗中心终止了与作为调查人员支持赠款的整个肿瘤学家小组的工作关系。这使拨款无效，并迫使NCI终止它。同一组肿瘤学家现在正申请在一个新的机构下恢复这项资助。莫比尔市有46%的非裔美国人，这个环境对于以少数族裔为基础的临床研究来说是理想的。此外，MBCCOP是区域迫切需要的社区资源。诊所的主要执业地点位于莫比尔市中心，该地区的少数民族在这些社区中集中度更高。合作小组已经在新的地点进行了研究，并设立了一个新的内部审查委员会。自终止以来，在过渡期间，申请人小组继续负责与MBCCOP有关的所有任务和责任，如跟进。作为该基金的前任项目负责人，康拉德博士进行了一项研究，调查非裔美国人不愿参与临床试验的原因。我们建议与康拉德博士合作，在这方面进行扩展，康拉德博士将担任该中心的顾问

DESCRIPTION (provided by applicant): The purpose of this application is to provide continued access to NCI supported Cancer Treatment, Prevention and Control trials for the residents of the mid-Gulf Coast region. The mid-Gulf Coast has been severely damaged over the past three years as a result of repeated natural catastrophes, first with partial destruction of Pensacola, FL by hurricane Ivan, then New Orleans, Biloxi/Gulfport by hurricane Katrina. Rebuilding is far from complete, and healthcare services have been adversely affected with still only basic medical care available in some of the affected areas. As a result, sustaining more complex subspecialty care at national levels remains a persistent challenge. Although Mobile was also declared a federally disaster zone after Katrina, it had recovered much quicker than the communities to the West. This permitted continuation of MBCCOP related activities with little downtime and also providing continuation of followups and protocol care for displaced cancer patients of that region. Even before the storms, the next closest structures capable of providing NCI supported cooperative group studies were located in Birmingham, AL to the North (260 miles), to the East in Gainesville, FL (390 miles), and New Orleans, LA with Tulane, LSD and the Ochsner clinic (150 miles). With LSU having completely lost their entire hospitals and oncology services Tulane did partially, and Ochsner's capacity also remains compromised. The Gulf Coast MBCCOP had accrued 103 new patients to protocols and was the fifth highest accruing CCOP for control and prevention trials in the country during the previous years, as well as having 617 active patients in followup. The Biloxi/Gulfport affiliates of the Gulf Coast MBCCOP remain closed since Katrina. For administrative and for reasons of competition, the Gulf Coast MBCCOP grantee Institution, Mobile Infirmary Medical Center terminated the working relationship with the entire group of oncologists who supported the grant as Investigators. This disabled the grant and forced the NCI to terminate it. The same group of oncologists is now applying to revive the grant under a new Institution. The environment is ideal for minority based clinical research with a 46 percent African American population in the city of Mobile. Moreover, a MBCCOP is a regionally desperately needed community resource. The primary practice location of the clinic is located in downtown Mobile, an area with even a much higher concentration of minorities in these neighborhoods. Cooperative group studies are already in place at the new site and a new IRB of record has been established. Since the termination, in the interim period, the applicant group continues to take care of all tasks and responsibilities related to the MBCCOP such as followups. The previous PI of the grant, Dr. Conrad had performed research to investigate causes for the reluctance of African Americans in participation in clinical trials. We propose to expand on this in collaboration with Dr. Conrad who will serve so- a consultant nn thic nrnnneal