Wireless System-on-a-Chip EEG IC For Animal Studies

描述(由申请人提供)：AME建议开发和测试一种重量不到4克的多通道数字无线头台，用于包括小鼠在内的小动物神经学研究。目前的无线头台对老鼠来说太重了。拟议的前台将通过使小鼠研究成为可能，推进无线动态动物神经监测的最先进水平，从而填补一个重要的市场空白。它还将使新的神经学研究成为可能。因为老鼠是可以在基因上操纵的，所以它们适应了其他物种不能进行的科学实验，比如大鼠。该设备将支持详细的动物神经学研究，这些研究支持包括阿尔茨海默氏症、亨廷顿病和癫痫在内的众多研究领域。由于极低功率、高数据速率、无线无线电的发展，鼠标的数字无线前台直到最近才成为可能。美国一家主要半导体制造商最近一直在开发用于植入式设备和助听器的高数据速率无线电技术，这些设备和助听器需要最少的外部组件和低功率(~1 mW)。功耗比其他无线解决方案低一个数量级以上，如建议用于RAT头台的蓝牙。这种低功率无线电技术是实现数字无线头台的必要技术，同时满足鼠标头台的严格低重量要求。第二阶段将制造定制IC、混合电路板和模压塑料封装，以生产该设备。将使用常见的入耳式助听器组装技术来实现低质量。最终的设备将进行全面评估。该设备将支持详细的动物神经学研究，这些研究支持包括阿尔茨海默氏症、亨廷顿病和癫痫在内的众多研究领域。

DESCRIPTION (provided by applicant): AME proposes to develop and test a multi-channel digital wireless headstage that weighs less than 4 grams for use in small animal neurological studies including mice. Current wireless headstages are too heavy for mice. The proposed headstage will advance the state-of-the-art in wireless ambulatory animal neurological monitoring by enabling mouse studies, and, thus, filling an important marketplace void. It will also enable new neurological research. Because mice are genetically manipulable, they accommodate scientific experiments that are unavailable in other species, such as rats. This device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy. A digital wireless headstage for mice has only recently been made possible due to developments in very low power, high data rate, wireless radios. A major US semiconductor manufacturer has recently been developing high data rate radio technology for implantable devices and hearing aids requiring minimal external components and low power (~1mW). The power consumption is more than an order of magnitude lower than other wireless solutions, such as Bluetooth, which has been proposed for rat headstages. This low power radio technology is necessary to achieve a digital wireless headstage while meeting the strict low weight requirements of headstages for mice. The phase II will fabricate a custom IC, the hybrid circuit board and the molded plastic package to productize the device. Techniques common to in-the-ear hearing aid assembly will be used achieve the low mass. The final device will be fully evaluated. This device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy.