CORE--ANALYTICAL LABORATORY

该设施为中心研究人员的研究兴趣相关的分子提供具有成本效益和准确的化学分析。它也是与分析化学中分析物的量化和策略相关的咨询基础。提供先进方法的服务和专业知识，包括最先进的技术，特别是液相色谱质谱法（LC/MS）和气相色谱质谱法（GC/MS）。此外，还向研究者提供临床标志物的常规分析和测定。在夏威夷州没有其他实验室可以提供这些服务。通过参加内部和外部质量保证计划，包括参加国家标准和技术研究所组织的循环测试，不断监测服务的高质量。该共享资源的可用性提供了最先进的服务，改善了对研究者的反馈，促进了跨学科合作，并为CRCH研究者提供了更具成本效益的服务。预计在可预见的未来，目前的满负荷使用将继续下去。需要该资源服务的新资助项目数量将超过明年终止的项目数量。在本周期内通过支助小组支助赠款获得的设备大大提高了这一资源的潜力。该设施自成立以来已显示出显着的增长，其价值中心的研究反映在其广泛的使用，目前服务的11 CRCH调查员从所有三个程序，在过去的四年中增加了两倍多的服务输出，并在2001 - 2004财年利用共享资源发表了32篇同行评议的手稿。

This facility provides cost-effective and accurate chemical analyses for molecules relevant to research interests of Center investigators. It is also a base for consultation related to the quantisation of analytes and strategies in analytical chemistry. Services and expertise in advanced methods are available including state-of-the-art techniques, particularly liquid chromatography mass spectrometry (LC/MS) and gas chromatography mass spectrometry (GC/MS). In addition routine analyses and determinations of clinical markers are offered to investigators. No other laboratories are available to provide many of these services in the State of Hawaii. The high quality of services is continually monitored by taking part in internal and external quality assurance programs including the participation in round robin tests organized by the National Institute of Standards and Technology. The availability of this Shared Resource provides state-of-the-art services, improves feedback to the investigators, stimulates inter-disciplinary collaborations, and provides more cost-effective service to CRCH investigators. The current use at full capacity is anticipated to continue for the foreseeable future. Newly funded projects requiring services of the resource will outnumber projects terminating in the coming year. Equipment obtained through the CCSG support grant in the current cycle has greatly enhanced the potential of this resource. This facility has shown remarkable growth since its inception and its value to Center research is reflected in its broad usage, currently servicing eleven CRCH investigators from all three Programs, more than a twofold increase in service output the past four years, and the publication of 32 peer reviewed manuscripts in FY01-FY04 utilizing the shared resource.