Medical Adhesive for Trauma-Free Bandage Removal

描述（由申请人提供）：伤口愈合技术发展迅速，先进的敷料不断加快愈合速度，减少感染，并显着提高患者的舒适度。每年都会推出新的敷料；然而，仍然需要强附着力的绷带敷料，以减少重复使用和皮肤脆弱相关的皮肤创伤风险。这一要求对于非常年轻和高龄的患者来说是最重要的，因为最小化皮肤创伤是至关重要的。该项目提出开发一种新的生物相容性聚合物-纳米材料粘合剂系统，该系统能够在可见光激活时从强粘附接触（开）状态切换到低粘附释放（关）状态。与传统敷料相比，这些可释放胶粘剂在激活时的剥离强度显著降低，从而减少了移除时的局部创伤。该项目的具体目标包括：(1)设计和合成含有富勒烯活性成分的新型生物相容性丙烯酸粘合剂；(2)在聚合物体系中加入纳米材料并优化添加剂浓度；(3)辐射交联与分子事件监测——优化辐射动力学和光功率；(4)新型胶粘剂的表征——评估摩尔质量增加对机械性能的影响作为温度的函数；(5)测定样品的水汽透过率，采用直杯试验法；(6)利用人造皮肤模型对原型粘合剂的皮肤刺激性和光毒性进行初步筛选。添加富勒烯增敏剂和暴露在可见光下，由于原位生成的化学物质引发交联反应，导致聚合物粘合剂的形态发生变化。在此过程中，我们还将首次测试新发现的金属氮化富勒烯（MNF）作为交联聚合物添加剂。本研究中的反应速率将由(1)添加剂的百分比和(2)可见光照射时间和灯功率控制。胶粘剂的机械性能将通过标准剥离和剪切试验来评估。玻璃化转变，存储和损耗模量将由DSC和DMA分析确定。

DESCRIPTION (provided by applicant): Wound healing technologies are growing rapidly, and advanced dressings are continuing to accelerate healing rates, reduce infection, and significantly improve patient comfort. Each year new dressings are introduced; however, there still exists a need for strongly adhering bandage dressings that will reduce the risk of skin trauma associated with repeated use and skin frailties. This requirement is most important to very young and advancing age patients - where minimizing skin trauma is paramount. This project proposes the development of a new biocompatible polymer - nanomaterial adhesive system which is capable of being switched from a strongly adhering contact (on) state to a low-adhering release (off) state, when activated by visible light. These releasable adhesives would exhibit a significant reduction in peel strength on activation, which results in reduced localized trauma upon removal when compared to conventional dressings. The specific aims of the project include the (1) design and synthesis of new biocompatible acrylic adhesives containing fullerene active compositions; (2) addition of nanomaterials into polymeric systems and optimize additive concentration; (3) radiation crosslinking and monitoring of molecular events - optimize radiation kinetics and light power; (4) characterization of new adhesives - assess the influence of molar mass increase in the mechanical performance as a function of temperature; (5) determination of the moisture vapor transmission rate of prototypes, using the upright-cup test method; and (6) initial screening to estimate skin irritation and phototoxicity of prototype adhesives using an artificial skin model. Addition of fullerene sensitizers and exposure to visible light induces morphology changes in the polymer adhesive due to in-situ generated chemical species, which initiate crosslinking reactions. During this effort, we will also test for the first time the newly discovered metallic nitride fullerene (MNF) species as cross-linking polymer additives. The rate of reactions in this study will be controlled (1) by the percent of additive and (2) by visible light exposure time and lamp power. Adhesive mechanical properties will be evaluated by standard peel and shear tests. Glass transitions, storage and loss modulus will be determined by DSC and DMA analysis.