RNA Localization 2006

描述(由申请者提供)：为FASE B和EMBO主办的细胞内RNA运输和本地化翻译会议提供部分支持。这次会议的主要目标是帮助促进科学交流，并促进在被广泛认为是关键的基因调控过程中取得进展。RNA转运和翻译调控是影响神经元突触生长和可塑性、胚胎分化和体平面形成以及细胞不对称产生等重要生物学现象的重要因素。在更大的层面上，RNA运输和局部翻译对神经生物学、发育生物学和细胞生物学等学科至关重要。最近的工作表明，RNA的运输和翻译机制被许多生物在其生命周期的不同阶段使用。因此，这次会议将吸引各种各样的研究人员，他们在从事不同的系统和科学研究领域的工作时，都有共同的兴趣，即确定mRNA如何运输到特定的亚细胞位置，以及它们的翻译如何受到控制。会议将强调调节RNA运输和局部翻译的机制和分子；主题将从X射线结晶学到运输中分子的体内成像。会议还将包括关于RNA结合蛋白和微小RNA对mRNA翻译的生化控制的演讲。这次会议的跨学科性质将吸引分子、细胞、发育和神经生物学科学家。

DESCRIPTION (provided by applicant): Partial support is requested for a FASEB and EMBO-sponsored conference on Intracellular RNA Transport and Localized Translation. The major goals of this meeting are to help foster scientific exchange and stimulate progress in what are widely regarded as critical processes of gene regulation. RNA trafficking and translational control are major influences on such important biological phenomena as neuronal synapse growth and plasticity, embryonic differentiation and formation of the body plan, and the generation of cellular asymmetry. On a larger level, RNA transport and local translation are centrally important for neurobiology, developmental biology, and cell biology, among other disciplines. Recent work indicates that the mechanisms of RNA transport and translation are used by many organisms at different stages of their life cycles. Thus, this meeting will attract a wide variety of investigators who, while working on diverse systems and areas of scientific inquiry, have the common interest of determining how mRNAs are transported to particular subcellular locations and how their translation is controlled. The conference will emphasize the mechanisms and molecules that regulate RNA transport and local translation; the subjects will range from x-ray crystallography to in vivo imaging of molecules in transit. The conference will also include presentations on the biochemical control of mRNA translation by RNA binding proteins and micro RNAs. The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists.