Neurotransmitter Function, Psychiatric Disorders, & MRS

描述（由申请人提供）：本次研讨会将主要集中在精神疾病，包括情绪障碍，精神分裂症，滥用物质，如酒精和尼古丁。研讨会有三个主要目标：（1）主要参与技术开发的研究人员和专注于神经精神研究的研究人员之间的思想和信息交流。(2)精神病学应用研究人员的技术教育。(3)面向技术研究者的精神药理学和病因学教育。与会者将包括来自技术和应用领域的知名研究人员，但将特别强调鼓励年轻研究人员的出席和参与。方法：该计划将包括一个为期两天半的研讨会的发言者的国际名册。观众预计将包括来自世界各地的150-250名研究人员。会议日期为10月13日至15日。拟议的议程将包括2个主要议题：神经精神疾病中的神经递质功能：病理生理学和治疗中的作用，以及磁共振波谱（MRS）方法。为期两天半的会议的大纲是：会议前的介绍性演讲：MRS的基本知识：什么是旋转？什么是填隙？我们怎么得到信号？关于精神疾病，我们需要了解什么？一般的成像和光谱学如何帮助我们更多地了解关键问题领域？与精神疾病相关的神经回路和神经递质功能综述。关于MRS方法和精神病学应用的全体会议：教学演讲（每个30”），然后是关于当前研究的提供，评论论文（每个10分钟），最后是公开讨论。治疗的新方向和应用：关于临床应用的讨论，从基础研究到制药工业的过渡。评论：主题将包括诊断和治疗成功的预测因素;治疗标志物;神经回路;细胞内靶点;基因表达等。青年研究者旅行奖是该计划的重要组成部分。《生物医学核磁共振》的编辑Chris Boesch已经同意考虑发表同行评审的论文，这些论文是关于会议期间提出的前沿工作的。磁共振波谱（MRS）是一种成像技术，其尖端应用可能会对临床研究人员构成令人生畏的技术障碍，我们对神经递质功能和调节的了解已经达到了一个点，在这个点上，受过技术培训的MRS研究人员可能缺乏临床应用知识和相关问题，以应用他们的先进技术。本次研讨会将促进来自这两个领域的研究人员的交叉教育，这是必要的，以最大限度地提高机会和精神疾病的神经递质功能的转化研究的质量。

DESCRIPTION (provided by applicant): This workshop will be focused primarily on psychiatric disorders, including mood disorders, schizophrenia, and abuse of substances such as alcohol and nicotine. The workshop has three primary goals: (1) Exchange of ideas and information between investigators involved primarily in technical development and those focused on neuropsychiatric research. (2) Technical education for psychiatric applications researchers. (3) Psychopharmacologic and etiologic education for technically oriented researchers. Attendees will include established researchers from technical and applications areas, but a special emphasis will be made to encourage attendance and participation by young investigators. METHODS: The program will include an international roster of speakers in a two and a half-day symposium. The audience is expected to include 150-250 researchers from around the world. The proposed meeting dates are October 13-15. The proposed agenda will include 2 main topics: Neurotransmitter function in neuropsychiatric disorders: pathophysiology and role in treatment, and Methods of Magnetic Resonance Spectroscopy (MRS). A general outline for the two and a half day meeting is: Introductory Lecture night before conference: Very basics of MRS: What is spin? What is shimming? How do we get a signal? Plenary Presentations What do we need to know about psychiatric disorders? How can imaging in general and spectroscopy in particular, help us learn more about key problem area? Review of neurocircuitry and neurotransmitter function related to psychiatric disorders. Plenary Sessions on each of the MRS methods and psychiatric applications: Teaching talks (30" each) followed by proffered, reviewed papers on current research (10 min each), concluding with open discussion. New Directions and Applications to Treatment: Talks on clinical applications, transition from basic research to pharmaceutical industry. COMMENTS: Topics will include predictors of diagnosis and treatment success; markers for treatment; neurocircuitry; intracellular targets; gene expression, etc. A call for abstracts will bring forward names and ideas from other groups that might be added to the main program. Young Investigator travel awards form an important part of this program. The editor of NMR in Biomedicine, Chris Boesch, has agreed to consider publishing peer-reviewed papers on cutting-edge work presented in the sessions in the conference. Magnetic resonance spectroscopy (MRS) is an imaging technology whose cutting edge applications can pose an intimidating technological barrier to clinical researchers, and our knowledge of neurotransmitter function and regulation has reached a point at which technically trained MRS researchers may lack knowledge of clinical applications and associate issues to apply their advanced techniques. This workshop will promote the cross-education of investigators from both areas, which is necessary to maximize the opportunities for and quality of translational research on neurotransmitter function in psychiatric disorders.