Analysis of an ADHD Whole Genome Association Scan

描述（由申请人提供）：GAIN计划将完成来自PI的国际多位点ADHD遗传学（IMAGE）项目的956个亲子三人组的600，000个标签SNP全基因组关联扫描。在本提案中，我们要求为分析这些数据提供资金。该提案的总体目标是完成对全基因组扫描（WGAS）数据的全面分析，以便深入了解ADHD的遗传病因和相关特征。我们将通过完成以下工作来实现这一点：1）评估GAIN SNP与ADHD诊断表型的关联，2）对GAIN三人组家庭中的兄弟姐妹的基因型进行插补，3）评估GAIN SNP与定量ADHD表型的关联，4）进行拷贝数分析，5）评估起源效应的父母; 6）评估出生季节效应和7）测试上位性。IMAGE项目目前正在通过NIMH遗传数据库与科学界分享研究的临床和遗传数据，为ADHD的分子遗传研究创建一个国际资源。我们样本中的所有临床和DNA数据已发送到NIMH DNA和临床数据库，以便向科学界发布。GAIN全基因组关联扫描产生的所有基因型数据将在基因型完成后立即提供给科学界。

DESCRIPTION (provided by applicant): The GAIN program will complete a 600,000 tag SNP genome-wide association scan of 956 parent-child trios from the PI's International Multi-site ADHD Genetics (IMAGE) project. In this proposal we are requesting funds for the analysis of these data. The overarching aim of this proposal is to complete a comprehensive analysis of the whole genome scan (WGAS) data in a manner that will provide insights into the genetic etiology of ADHD and associated features. We will do this by completing the following: 1) assessing the association of GAIN SNP's with the ADHD diagnostic phenotype, 2) Imputing genotypes for siblings in the GAIN trio families, 3) Assessing the association of GAIN SNP's with the quantitative ADHD phenotypes, 4) conducting copy number analyses, 5) assessing parent of origin effects; 6) assessing season of birth effects and 7) testing for epistasis. The IMAGE project is now in the process of creating an international resource for molecular genetic studies of ADHD by sharing the study's clinical and genetic data with the scientific community through the NIMH genetic data repositories. All clinical and DNA data from our samples has been sent to the NIMH DNA and clinical data repositories for release to the scientific community. All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed.