Calcium Foods and Bone Health of Adolescent Girls

骨质疏松症是一个主要的公共卫生问题。骨骼在青年时期的最佳发育是至关重要的 在预防骨质疏松症中，由于骨量减少而在晚年发生骨折的一种状态 和骨骼质量。如果骨骼发育能在生长过程中最大化，年轻人就会开始 成年人拥有最佳的骨骼健康，晚年患骨质疏松症的可能性较小。然而，骨骼健康 青年问题尚未得到充分解决。在本申请中，我们建议延长我们为期4年的干预 高钙饮食对青春期女孩骨骼质量影响的研究。这个实验的目的是 这项研究旨在测试将膳食钙摄入量增加到每天1500毫克对提高老年人骨骼质量的影响 青春期女性。需要检验的假设是：食用高钙饮食的青春期女性 在密度测量和超声波测量中，骨骼质量比青春期女性有更大的提高 他们通常会摄入日常饮食中的钙。这项研究采用了一种实验设计，其中58 受试者(26名治疗组和32名对照组)将被跟踪观察总计9.5年。参与者是 入学时年满9岁的方便样本。治疗组中的女孩将继续接受 每天至少供应1500毫克的高钙食物，而对照组的女孩将要求继续 吃着他们平常的饮食。在基线、每六个月和研究结束时进行测量 包括：通过密度测量和超声波测定的骨骼质量、身高、体重、皮肤晒黑阶段和医学检查 和社会史。通常的体力活动和饮食摄入量将每三个月确定一次。资金来源 下一个周期的这个项目将使我们能够连续跟踪这些年轻的雌性从9岁到 18.5.据我们所知，这将是评估最佳钙摄入量效果的第一次干预。 在骨量和骨质量最高的时期对骨健康的影响。至关重要的是我们要 利用这个机会。这群热情的青少年参与者给了我们信心 我们能够成功地完成这一雄心勃勃的项目。增加钙的积极作用的证据 从食物来源摄取对青春期女性骨骼质量的影响将为教育提供强有力的支持 针对青春期女性、父母和护理提供者的努力。积极的发现也将提供 推动更多吸引年轻女性的食物补钙。缺乏钙的影响会 为进一步研究最大化骨骼的其他方法或伴随方法提供支持 发展。

Osteoporosis is a major public health problem. Optimum development of the skeleton during youth is crucial in prevention of osteoporosis, a condition in which fractures occur late in life because of reduced bone mass and bone quality. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone health and be less likely to develop osteoporosis in later years. Yet bone health of youth has not been adequately addressed. In this application, we propose to extend our 4-year intervention study of the effects of a high calcium diet on bone quality in pubertal girls. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in adolescent females. The hypothesis to be tested is: adolescent females who consume a high calcium diet will have a greater increase in bone quality, as measured by densitometry and ultrasound, than adolescent females who consume their usual dietary calcium intake. The study uses an experimental design in which 58 participants (26 treatment and 32 control) will be followed for a total of 9.5 years. Participants are a convenience sample who were age 9 when enrolled. Girls in the treatment group will continue to be given high calcium foods to supply at least 1500 mg/day, while girls in the control group will asked to continue consuming their usual diet. Measurements to be made at baseline, every six months, and at the end of study include: bone quality determined with densitometry and ultrasound, height, weight, Tanner stage, and medical and social history. Usual physical activity and dietary intake will be determined every three months. Funding of this project in the next cycle would enable us to follow these young females continuously from age 9 to 18.5. To our knowledge, this would be the first intervention to evaluate the effects of optimal calcium intake on bone health throughout the period of highest bone mass and bone quality accrual. It is critical that we take advantage of this opportunity. This enthusiastic group of adolescent participants provides us with confidence that we can successfully complete this ambitious project. Evidence of a positive effect of increased calcium intake from food sources on bone quality in adolescent females would provide strong support for educational efforts targeted at adolescent females, parents and care providers. Positive findings would also provide the impetus for calcium fortification of more foods that appeal to young females. Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development.