Northern California Comprehensive Sickle Cell Centers

北加州综合镰状细胞中心（NCCSCC）的目标是：1)促进血红蛋白病的基础研究、临床科学、疾病的社会心理方面的研究；并启动多中心合作研究项目，为受影响人群提供血红蛋白病检测、咨询、教育和护理。为了实现这些目标，我们在奥克兰儿童医院研究所（CHORI）和加州大学旧金山分校（UCSF）建立了相互依存的基础研究项目。这些基础项目由西湾（UCSF/旧金山总医院）和东湾（奥克兰儿童医院）的核心临床研究项目补充。这些项目为参与NCCSCC研究的700多名镰状细胞病（SCD）患者提供血红蛋白病检测、咨询、教育和综合护理，以维持一个稳定、特征明确的群体

The objectives of the Northern California Comprehensive Sickle Cell Center (NCCSCC) are:1) to facilitate hemoglobinopathy research in the areas of basic research, clinical science, psychosocial aspects of the disease; and to initiate multicenter collaborative research projects 2) to provide hemoglobinopathy detection, counseling, education and care to affected populations. To pursue these objectives, we have developed interdependent basic research programs at Childrens' Hospital Oakland Research Institute (CHORI) and University of California at San Francisco (UCSF). These basic programs are complemented by core clinical research programs in the West Bay (UCSF/San Francisco General Hospital) and in the East Bay (Childrens' Hospital Oakland]. These programs provide hemoglobinopathy detection, counseling, education and comprehensive care needed to maintain a stable, well characterized group of over 700 patients with sickle cell disease (SCD) who participate in NCCSCC research projects. Clinical, basic and collaborative network research projects aims are: A) To initiate a phase lla, randomized, trial to determine if LY315920 [anti PLA 2 inhibitor] can be safely used to prevent impending ACS and to characterize the mechanisms by which it prevents damage. B) To determine the extent of neurocognitve and neuromimaging abnormalities in neurologically asymtomatic adult SCD patients. C) To understand the mechanisms that result in phospholipid asymmetry in red cell membranes and to determine their in vivo significance in SCD patients by studying physiological processes. D) To construct sickle cell mice utilizing BAC's to isolate the beta-globin clusters from patients with the four sickle haplotypes: Benin, CAR, Senegal and Saudi Arabia, and to study their pathophysiology and rheology. E) Our network project's aim is to test hypothesis that a non-myeloablative conditioning regimen in young adults with symptomatic SCD a can induce stable donor host hematopoietic chimerism after stem cell transplantation from HLA identical sibling donors.