Group A streptococcal human challenge study: accelerating vaccine development

A组链球菌（GAS）感染是全世界发病和死亡的主要原因，包括澳大利亚土著人口。由于缺乏合适的动物模型，疫苗开发的协调努力受到阻碍。为了解决这一关键的知识差距，我们建议开发一个GAS感染的受控人类感染模型。该模型将为未来新型GAS疫苗的评价提供直接途径。

Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.