Group A streptococcal human challenge study: accelerating vaccine development

感染A组链球菌(GAS)是全世界发病率和死亡率的主要原因，包括在澳大利亚的土著人口中。由于缺乏合适的动物模型，疫苗开发的共同努力受到了阻碍。为了解决这一关键的知识鸿沟，我们建议开发一种气体感染的受控人类感染模型。该模型将为未来新型GAS疫苗的评价提供一条直接的途径。

Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.