Growth factor directed developmental and pathological lymphangiogenesis

新淋巴管的形成发生在正常发育中以及癌症和心血管疾病的病变组织中。我们已经了解了发育过程中神经元是如何形成的，但我们对疾病中神经元是如何形成的了解得少得多。该项目将应用多学科方法，包括遗传学和计算生物学，以比较发育和疾病中的遗传学形成。我们希望发现新的方法来操纵这个过程，以获得治疗效果。

The formation of new lymphatic vessels occurs in normal development and in diseased tissues in cancer and cardiovascular disease. We have developed an understanding of how lymphatics form in development but we understand far less about how they form in disease. This project will apply multidisciplinary approaches, including genetics and computational biology, to compare how lymphatics form in development and disease. We hope to uncover new ways to manipulate this process for therapeutic gain.