Treatment for Adolescent Anorexia Nervosa

描述（由申请人提供）：神经性厌食症（AN）是一种严重的心理疾病，在15-19岁的青少年女性中的患病率估计为0.48%。在青少年中，这种疾病严重影响身体，情感和社会发展。到目前为止，还没有大规模的青少年AN治疗研究。然而，小规模的研究表明，一种特定类型的以家庭为基础的治疗（FT）是一种有效的方法，青少年发病AN。这项多中心研究的目的是比较这种特定的家庭治疗（FBT）与自我导向的个体心理治疗（EOIT），以确定哪种治疗更有效。 该研究有两个具体目的：（1）比较FBT和EOIT对青少年AN的相对疗效。我们将专门研究体重增加，对体重和形状的心理担忧以及家庭功能的变化。(2)检查潜在的预测因子、中介因子和调节因子。 为了实现这些目标，提出了以下研究：在两个中心（每个中心60例），将120例符合DSM-IV AN标准的12-18岁青少年随机分配至两个治疗组之一：1）FBT（手动），24个计划患者小时，持续12个月;或2）EOIT（手动），24个计划患者小时，持续12个月。 所有患者将在治疗结束后随访1年。将在基线、治疗结束、6个月和1年随访时进行评估。主要结局是体重变化。次要结果将是通过饮食失调检查测量的体重和形状问题的变化。

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychological condition with a prevalence estimated at 0.48% among adolescent females between 15-19 years. In adolescents, the illness severely affects physical, emotional, and social development. To date, there are no large-scale treatment studies of adolescents with AN. Smaller scale studies, however, suggest that a specific type of family-based treatment (FT) is an effective approach to adolescent onset AN. This multi-site study aims to compare this specific family therapy (FBT) with ego oriented individual psychotherapy (EOIT) to determine which treatment is more efficacious. The study has two specific aims: (1) To compare the relative efficacy of FBT and EOIT in adolescents with AN. We will specifically examine weight gain, psychological concerns about weight and shape and changes in family functioning. (2) To examine potential predictors, mediators and moderators of outcome. To accomplish these aims the following study is proposed: at two centers (60 per center), 120 adolescents between the ages of 12-18 meeting DSM-IV criteria for AN will be randomly assigned to one of two treatment groups: 1) FBT (manualized) for 24 planned patient hours for 12 months; or 2) EOIT (manualized) for 24 planned patient hours over 12 months. All patients will be followed for 1 year after the end of treatment. Assessment will occur at baseline, end of treatment, and six months and one-year follow-up. Primary outcome will be weight change. Secondary outcomes will be changes in weight and shape concerns as measured by the Eating Disorder Examination.