Evaluation Of Treatments Of Drug Dependence In HIV Infec

该项目评估减少药物滥用者艾滋病毒风险行为的方法，并评估药物和行为治疗对已感染艾滋病毒的阿片类药物依赖的安全性和有效性。我们以前已经表明，美沙酮维持治疗对减少艾滋病毒风险行为具有广泛的有益作用，当增加行为干预措施时，CBT对减少性风险行为的额外益处有限。 在过去的一年里，我们研究了艾滋病毒风险行为与丙型肝炎感染之间的关系。数据显示，在海洛因/可卡因双重使用者治疗研究项目中，约有一半的参与者感染了丙型肝炎。那些感染丙型肝炎的人更有可能在治疗开始前报告从事艾滋病毒风险行为，特别是那些与注射毒品有关的行为。在治疗期间，丙型肝炎阳性参与者报告艾滋病毒风险行为的发生率下降。丙型肝炎感染不影响治疗期间不良医疗事件的发生率。我们正在继续探索艾滋病毒风险与丙型肝炎感染和预防之间的关系。

This project assesses methods for decreasing HIV-risk behaviors in substance abusers, and assesses the safety and efficacy of pharmacological and behavioral treatments for opioid dependence in those already infected with HIV. We have previously shown that methadone maintenance has broad beneficial effects of reducing HIV risk behaviors, with limited additional benefit from CBT for reduction of sexual risk behaviors when augmented with behavioral interventions. In the past year we examined the relationship between HIV-risk behaviors and infection with hepatitis C. Data showed that approximately one half of participants in a treatment research project for dual heroin/cocaine users were infected with hepatitis C. Those infected with hepatitis C were more likely to report engaging in HIV-risk behaviors, especially those related to injection drug use, prior to treatment entry. During treatment, hepatis C-positive participants reported decreased rates of HIV-risk behaviors. Infection with hepatitis C did not affect rate of adverse medical events during treatment. We are continuing to explore the relationship between HIV risk and hepatitis C infection and prevention.