Gated Optical DetectorsDose Guided Radiotherapy

已经进行了幻影研究。已经发表了初步研究，正在准备对剂量学参数进行全面评估。与传统的体内测量方法相比，目前正在进行有限的临床评估，以确定该系统的日常用途。后续的三个阶段项目是开发用于剂量引导放射治疗(DGR)的探测器阵列。第一阶段是将纤维阵列发展为矩形或螺旋网格，并研究放射治疗期间产生的剂量图以及器官或射束位置的微小变化的影响。第二阶段是了解相对于患者解剖位置的信号变化的意义，如果检测到的信号与参考值相差预定的容差，则中断治疗。第三阶段是将网格信号的变化与辐射场的校正变化动态地联系起来，以便在线、动态地控制放射治疗的剂量。

Phantom studies have been performed. Preliminary studies have been published and a comprehensive assessment of dosimetric parameters is in preparation. Limited clinical assessment is underway to determine the day-to-day utility of this system as compared with conventional in-vivo measurement methods.There is a follow-on three phase project to develop a detector array for dose-guided radiotherapy, or DGR. Phase I is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. Phase II is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. Phase III is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments.