GENETICS CORE

遗传学核心的目标是促进和促进糖尿病及其相关疾病的遗传学研究。 乔斯林糖尿病中心的人类和动物模型的并发症及其他合作 机构。为此，核心以DNA储存库和支助服务的形式提供资源 用于基因研究，如基因分型和协助数据分析。遗传学的这些功能 CORE将在下一个资助期间扩大，以满足人们对基因研究日益增长的兴趣 由于人类基因组序列的可获得性，对遗传变异的改进了解， 性价比高的基因分型方法的开发使基因研究得以史无前例的规模。 以下是下一个供资期间的目标： 1.利用正在进行的临床研究项目，扩大具有良好特征的DNA样本的收集 从而充分挖掘乔斯林糖尿病中心患者群的潜力。 2.通过升级单核苷酸多态(SNP)，扩大对遗传学研究的支持服务 从低吞吐量到中等吞吐量的基因分型服务，并提供DNA样本的基本基因图谱 核心的收藏。 3.建立一个强大的数据库，将所有研究的遗传数据联系起来，以协同提高价值 任何一项研究，并实现交叉实验分析。

The objective of the Genetics Core is to promote and facilitate genetic studies of diabetes and its complications in humans and animal models at the Joslin Diabetes Center and other collaborating institutions. To this end, the Core provides resources in the form of repositories of DNA and support services for genetic studies, such as genotyping and assistance with data analysis. Such functions of the Genetics Core will be expanded during the next funding period to meet the increasing interest in genetic studies spurred by the availability of the human genome sequence, the improved knowledge of genetic variation, and the development of cost-effective genotyping methods allowing genetic studies of unprecedented scale. The following are the objectives for the next funding period: 1. Expand the collection of well-characterized DNA samples by leveraging ongoing clinical research projects so that the potential of Joslin Diabetes Center's patient base is fully exploited. 2. Expand the support services for genetic studies by upgrading the single nucleotide polymorphism (SNP) genotyping service from low to medium throughput and provide basic genetic profiles of the DNA samples in the Core's collections. 3. Build a strong database to link genetic data across all studies in order to synergistically enhance the value of any one study and enable cross-experiment analyses.