DEFINING SALIVA PROTEIN IN NORMAL RHESUS MACAQUES USING PROTEINCHIP TECHNOLOGY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：我们的研究集中在唾液中存在的总蛋白质种类，从婴幼儿到成年的正常发育过程中唾液蛋白质的模式，或者唾液蛋白质在口腔中对病毒感染的保护作用的相对贡献。我们的研究基于一种假设，即恒河猴从出生到断奶的正常发育过程中，唾液蛋白质谱发生了显着变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Our proposed studies focus on the overall protein species present in saliva, the pattern of saliva proteins during normal development from infancy to adulthood or the relative contribution of salivary proteins to protective effect in oral cavity against viral infection. Our studies were based on the hypothesis that salivary protein profiles in rhesus macaques change significantly during normal development from birth to weaning.