Health Promotion in Minority Childhood Cancer Survivors

描述（由申请人提供）：儿科癌症治疗的进展已导致生存率的显着改善，超过75%的癌症儿童无病生存超过5年。因此，大约每900名16至44岁的成年人中就有一名儿童癌症幸存者。尽管在治疗方面取得了进展，但许多幸存者经历了治疗的不良晚期效应，如心血管疾病（CVD）和与治疗相关的继发性癌症的风险增加。这些晚期效应可能会因生活方式因素而加剧，包括肥胖，不健康的饮食，不活动和吸烟。因此，坚持促进健康的做法，如保持健康的饮食和体重，定期体育活动，避免吸烟，可能对儿童癌症的成年幸存者特别有益。目前，对儿童癌症成年幸存者的生活方式行为知之甚少。已经完成的研究主要包括非西班牙裔白色样本。事实上，对少数民族成年幸存者一无所知。拟议的项目是一项对非洲裔美国人、西班牙裔和非西班牙裔白色成年儿童癌症幸存者和非癌症对照的横断面观察性研究。该研究将描述和比较重要的健康行为（饮食，体育活动，吸烟）和特定的医疗保健，社会文化，认知和环境因素（健康状况，医疗保健利用，文化信仰/实践，灵性，健康知识，态度，自我效能和社会支持）假设影响所确定的健康行为。使用回归分析，我们将制定预测模型，解释幸存者的地位，种族和健康行为之间的关系，以及介导这些行为的社会文化和认知因素。这项研究的结果将被用来协助设计一个可行的干预措施，以增加少数民族幸存者的积极健康行为。

DESCRIPTION (provided by applicant): Advances in the treatment of pediatric cancers have led to dramatic improvements in survival and over 75 percent of children with cancer survive disease-free for more than 5 years. As a result, approximately one in every 900 adults between the ages of 16 and 44 is a survivor of pediatric cancer. Despite advances in treatment, many survivors experience adverse late effects of treatment such as increased risk for cardiovascular disease (CVD) and secondary cancers related to treatment. These late effects may be compounded by lifestyle factors that include obesity, unhealthful diets, inactivity, and smoking. Therefore, adherence to health-promoting practices such as maintenance of a healthy diet and weight, regular physical activity, and avoiding smoking may be particularly beneficial to adult survivors of childhood cancers. Currently, little is known about the lifestyle behaviors of adult survivors of childhood cancers. Studies that have been done include primarily non-Hispanic White samples. Virtually nothing is known about ethnic minority adult survivors. The proposed project is a cross sectional observational study of African-American, Hispanic, and non- Hispanic White adult survivors of childhood cancers and non-cancer controls. The study will describe and compare important health behaviors (diet, physical activity, smoking) and specific health care, sociocultural, cognitive and environmental factors (health status, health care utilization, cultural beliefs/practices, spirituality, health knowledge, attitudes, self-efficacy and social support) hypothesized to influence the identified health behaviors. Using regression analyses we will formulate predictive models that explain the relationships between survivor status, ethnicity and health behaviors, and the sociocultural and cognitive factors that mediate these behaviors. The results from this study will be used to assist in the design of a feasible intervention to increase positive health behaviors in minority survivors.