Engineering haematopoietic microniches: the hematon project

血液是在骨髓中产生的。在骨髓中发现了小的细胞团，称为血球，它们能够产生血液中发现的所有类型的细胞。目前还不知道血球是如何做到这一点的，该项目的目的是找出它是如何做到的。为了做到这一点，我们将尝试在体外制造血球。因为我们在体外这样做，我们可以准确地控制血球的成分，根据血球所包含的不同细胞类型以及细胞外发现的物质。此外，我们还可以通过将不同的细胞引导到重建的血球中的特定位置来精确控制它们的位置。

Blood is produced in bone marrow. Within bone marrow small clumps of cells have been found, called hematons, which are able to produce all the types of cells found in blood. It is not known how a hematon is able to do this, and the aim of the project is to find out how it does. To do this, we will try to make hematons outside the body. Because we do it outside the body, we can exactly control the composition of the hematon, in terms of the different cell types it consists of as well as the material that is found outside the cells. In addition, we can also precisely control the position of the different cells by guiding them to specific positions within a reconstructed hematon.