FAMILIAL COLORECTAL NEOPLASIA LINKED TO CHROMOSOME 9Q222-312

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。结直肠癌是美国成年人癌症死亡的第二大原因。两种常染色体显性遗传形式的疾病，家族性腺瘤性息肉病和遗传性非息肉性结直肠癌，加起来约占所有病例的5%。然而，在大约20%的额外结肠癌病例中，受影响的个体报告有一级亲属的结肠癌家族史。在对53个家族进行基因组扫描后，其中2个或更多的兄弟姐妹受到65个结肠癌的影响，我们使用密集间隔的微卫星标记对9号和6号染色体进行了精细定位。我们在另外70个品种中进一步证实了这些信号。9号染色体上的信号强度增加了一个数量级。此外，该候选区域的SNP分型正在进行，几个候选基因的SNP分型也在进行中

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Colorectal cancer is the second most leading cause of cancer death among adult Americans. Two autosomal dominant hereditary forms of the disease, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, together account for perhaps 5%of all cases. However, in about 20% of additional colon cancer cases,the affected individuals report a family history of colon cancer in a first-degree relative. Following a genome scan in 53 kindreds in which 2 or more sibling were affected by 65 with colon cancer, we performed finemapping on chromosomes 9 and 6 using densely spaced microsatellite markers. We further confirmed these signals in an additional 70 kindreds. Signal strength on chromosome 9 was increased by an order of magnitude. Additionally SNP typing is now underway in this candidate region as is SNP typing of several candiate genes