MICROPET CHARACTERIZATION AND PRELIMINARY DATA (PHANTOMS AND ANIMALS)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。开发放射性示踪剂图像重建方法，使用MRI和/或CT图像以及microPET投影数据来估计放射性示踪剂的分布。这种方法将大大改善放射性示踪剂的量化、定位和检测。这些研究是拨款申请的初步结果，如果得到资助，将使杜克大学和其他NCI赞助的SAIRP设施扩大对改善小动物放射性示踪剂成像的研究。真实动物的多模式成像对于证明MRI和/或CT的潜力是必不可少的，以改进对真实的(而不是幻影的)放射性示踪剂分布的估计。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Develop radiotracer-image reconstruction methods that use MRI and/or CT images along with microPET projection data to estimate radiotracer distribution. Such methods would substantially improve radiotracer quantification, localization, and detection. These studies are preliminary results for a grant application which, if funded, would enable expanded research on improving small animal radiotracer imaging here at Duke and at other NCI-sponsored SAIRP facilities. Multi-modality imaging of real animals is essential to demonstrate the potential of MRI and/or CT to improve the estimation of realistic, rather than phantom, radiotracer distributions.