MULTIPLE MOUSE MRI

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项工作将开发必要的硬件、软件和技术，以便在MRI系统上对多个样本进行成像。首先，将构建必要的射频线圈、屏蔽和馈电结构，以连接7T成像系统，并检查各种扫描配置。采集图像，用信噪比和采集时间对图像进行表征。最后，开发必要的后处理软件，以消除叠叠，减少因隔离不良而产生的鬼影效果。最终将证明，信噪比效率（与单通道相比，给定采集时间的信噪比）可以比单通道提高N倍（通道数），从而接近Bock等人发表的理论最大效率（Mag. Res. Med., 49, 158-167, 2003）。最初将设计、制造和测试四个线圈。将测量线圈之间的隔离，并对每个射频线圈的相对质量进行表征。接收机链中的无源元件将被测量隔离和幅度/相位平衡。最终，渠道之间的隔离和平衡将最大化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work will develop the necessary hardware, software, and techniques for imaging multiple samples on a MRI system. First, the necessary RF coils, shields, and feed structures will be constructed to interface the 7T imaging system and various scanning configurations will be examined. Images will be collected and characterized by SNR and acquisition time. Finally, the necessary post-processing software will be developed to eliminate foldover and reduce the effects of ghost images caused by poor isolation. Ultimately it will be proven that SNR efficiency (SNR for a given acquisition time compared to a single channel) can be improved by a factor of N (number of channels) over that of a single channel, and thus approach the theoretical maximum efficiency published by Bock et. al. (Mag. Res. Med., 49, 158-167, 2003). Initially four coils will be designed, fabricated, and tested. Isolation between coils will be measured and the relative quality of each RF coil will be characterized. The passive components in the receiver chain will be measured for isolation and amplitude/phase balance. Ultimately isolation and balance will be maximized between channels.