ORIGINS OF FIBRE CRIMP FROM PROTEIN TYPE & STRUCTURE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本项目的目标是确定3-D安排的中间丝在三个皮质细胞类型（邻，中，和paracortex）在纵向切片的羊毛纤维。先前在科罗拉多博尔德的Bio 3-D实验室进行的工作集中在横切的羊毛纤维上。人们期望，更多的长程信息的安排，中间长丝将获得与纵向切片羊毛纤维。这些中间丝在三个不同皮层细胞中的排列对羊毛纤维的整体弯曲或卷曲起着重要作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to determine the 3-D arrangement of intermediate filaments in the three cortical cell types (ortho-, meso-, and paracortex) in longitudinally sectioned wool fibres. Previous work conducted at the Bio3-D lab in Boulder, Colorado focussed on transversely sectioned wool fibres. It is expected that more long-range information regarding the arrangements of the intermediate filaments will be obtained with longitudinally sectioned wool fibres. The arrangements of these intermediate filaments within each of three different cortical cells plays an important role in the overall curvature or crimp of the wool fibre.