Harnessing Extracellular Matrix Remodelling by Cancer-Associated Fibroblasts to Increase T Cell Infiltration of Solid Tumours

杀伤T细胞发现并消灭肿瘤细胞的能力是过继性转移免疫疗法的基础，迄今为止，这种疗法只对血液传播的癌症有效。实体瘤的T细胞不易浸润，主要是由于成纤维细胞的重塑，因此治疗实体瘤的成功率有限。我们发现T细胞在成纤维细胞在肿瘤基质中挖的隧道中迁移。在这里，我们将利用这一发现来改善实体肿瘤的浸润和排斥。

The ability of killer T cells to find and eliminate tumour cells is the basis for adoptive transfer immunotherapies, which thus far only work well with blood-borne cancers. There is limited success with solid tumours, which T cells do not readily infiltrate, notably because of remodelling by fibroblasts. We have discovered that T cells migrate in tunnels dug in the tumour matrix by fibroblasts. Here, we will harness this discovery to improve tumour infiltration and rejection of solid tumours.