Harnessing neural plasticity to improve functional outcomes following burn injury.

烧伤是痛苦的，并导致长期的功能障碍和慢性疾病的增加。疼痛和外周损伤诱导大脑的变化，可能是功能上有益的或适应不良的，但我们对烧伤后的大脑变化知之甚少。该项目将确定烧伤后神经可塑性的机制和功能影响，并测试神经干预在减轻烧伤后疼痛和改善功能恢复方面的疗效。

Burn is painful and leads to long-term functional impairment and increased chronic disease. Pain and peripheral injury induce changes in the brain that can be functionally beneficial or maladaptive, yet we know little about brain changes following burn injury. This project will identify the mechanisms and functional impact of neural plasticity after burn injury, and test the efficacy of a neural intervention to reduce pain and improve functional recovery following burn injury.