Synthesis and Study of Complex Natural Products

描述（由申请人提供）：复杂天然产物的基本化学和生物活性的研究是理解其作用机制和开发疾病治疗方法的关键。该研究计划旨在通过应用和开发有机合成的新策略和方法，开发结构复杂，化学复杂和生物活性天然产物的有效合成。受生物遗传学考虑的启发，追求提供潜在的更广泛的解决方案的化合物的家庭，同时提供洞察可能的生物合成途径负责其生物起源的策略。目标选择的基础上，有趣的和新的分子结构，缺乏以前的合成研究，生物活性，以及未来的化学和生物机制研究的潜力。 计划中的合成旨在开发新的复杂性生成反应序列，特别是多个碳-碳键形成级联，并挑战现有的合成方法，同时激发开发新的有效方法来合成复杂分子。

DESCRIPTION (provided by applicant): The study of the fundamental chemical and biological activity of complex natural products is key to understanding their mechanism of action and developing therapeutics for the treatment of diseases. This research program aims to develop efficient synthesis of structurally complex, chemically intricate and biologically active natural products through the application and development of new strategies and methodologies for organic synthesis. Strategies inspired by biogenetic considerations are pursued to afford potentially broader solutions to families of compounds while providing insight into the possible biosynthetic paths responsible for their biogenesis. Targets are selected on the basis of interesting and novel molecular architecture, paucity of prior synthetic studies, biological activity, and the potential for future chemical and biological mechanistic studies. The planned syntheses are designed to develop new complexity generating sequence of reactions, in particular multiple carbon-carbon bond forming cascades and to challenge existing synthetic methods in addition to inspire the development of new and efficient methodologies for the synthesis of complex molecules.