SLEEP AND NOCTURNAL ENDOCRINE FUNCTION IN MDMA USERS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。（+）3,4-亚甲基二氧甲基苯丙胺（MDMA，“摇头丸”）是一种日益流行的滥用精神药物，已被证明是一种有效的脑血清素（5-HT）神经毒素。娱乐性MDMA使用者中越来越多的证据表明，MDMA也会对人体产生5-羟色胺损伤，并且MDMA的使用可能导致睡眠和神经内分泌功能的改变。由于5-HT参与睡眠、昼夜节律模式和内分泌功能的调节，先前发现的睡眠和内分泌功能异常可能与mdma诱导的5-HT损伤有关。本研究旨在扩展以往MDMA使用者睡眠和神经内分泌功能的研究，并探索MDMA使用者和匹配对照者睡眠和夜间神经内分泌功能之间可能的相互关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (+)3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is an increasingly popular psychoactive drug of abuse that has been shown to be a potent brain serotonin (5-HT) neurotoxin in animals. Growing evidence in recreational MDMA users indicates that MDMA can also produce 5-HT damage in humans, and that MDMA use may lead to alterations in sleep and neuroendocrine function. Since 5-HT is involved in the regulation of sleep, circadian patterns, and endocrine function, previously identified abnormalities in sleep and endocrine function may be related to MDMA-induced 5-HT injury. The proposed studies are intended to extend previous studies of sleep and neuroendocrine function in MDMA users, and explore possible interrelations between sleep and nocturnal neuroendocrine function in MDMA users and matched controls.