PREVENTION OF MICROGRAVITY-INDUCED STONE RISK

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。广泛的长期目标是评价对策在预防空间飞行期间肾结石形成和骨骼矿物质流失倾向增加方面的有效性。 在本项目中待检验的假设是，补充柠檬酸钾镁将降低结石形成的风险，并减少微重力引起的骨丢失。 在正常志愿者卧床休息五周期间，将通过三个特定目标对该假设进行检验：1-评估补充柠檬酸钾镁（KMgCit）在预防微重力诱导的肾结石形成风险增加方面的功效; 2-评估补充KMgCit在避免微重力诱导的肌肉萎缩期间可能发生的肌肉镁和钾浓度降低方面的作用;以及3-评估补充KMgCit在减少微重力诱导的骨吸收增加和尿钙丢失方面的功效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The broad long-term objective is to evaluate the effectiveness of a countermeasure in the prevention of increased propensity for renal stone formation and skeletal mineral loss sustained during space flight. The hypothesis to be test in this project is that potassium magnesium citrate supplementation will attenuate the increased risk for stone formation and diminish microgravity-induced bone loss. The hypothesis will be tested during five weeks of bedrest in normal volunteers through three specific aims: 1- assess the efficacy of supplementation with potassium magnesium citrate (KMgCit) in preventing microgravity-induced increased risk of renal stone formation 2- evaluate the effect of KMgCit supplementation in averting diminished muscle magnesium and potassium concentrations that may occur during microgravity-induced muscle atrophy and 3- assess the efficacy of supplementation with KMgCit in reducing microgravity-induced increases in bone resorption and urinary calcium losses.