METABOLIC ABNORMALITIES IN HISPANIC CHILDREN WITH CYSTIC FIBROSIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一般来说，西班牙裔囊性纤维化(CF)患者的发病率和死亡率比高加索人CF患者更差。然而，这种恶化状态的潜在机制(S)尚未阐明。这项研究/赠款的目的是探索潜在的代谢解释，以解释患有CF的西班牙裔儿童的临床状况恶化的原因。中心假说是，高血糖在患有CF的西班牙裔人中较年轻时发生，主要是由继发于西班牙裔遗传的潜在胰岛素抵抗引起的。进一步假设胰岛素抵抗包括肝脏胰岛素抵抗和抵抗胰岛素的抗分解代谢作用，从而导致糖异生的氨基酸底物过多。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In general, cystic fibrosis (CF) patients who are Hispanic have worse morbidity and mortality than Caucasian CF patients. However, the underlying mechanism(s) for this worsened status has not been elucidated. The purpose of the study/grant is to explore potential metabolic explanations for the worsened clinical status of Hispanic children with CF. The central hypothesis is that hyperglycemia occurs at a younger age in Hispanics with CF and that it is principally caused by underlying insulin resistance secondary to the Hispanic heredity. It is further hypothesized that insulin resistance includes hepatic insulin resistance and resistance to insulin's anti-catabolic effect which results in excessive amino acid substrate availability for gluconeogenesis.