WEIGHT LOSS IN PUBLIC HOSPITAL BREAST CANCER PATIENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项预先设定的随机试验的具体目的是在50名患有乳腺癌的绝经后妇女中检验以减肥为目标的治疗生活方式改变干预措施与对照条件的效果，其中包括低卡路里饮食和中等强度运动计划：主要目的：体重变化和胰岛素抵抗变化，通过以下指标估计：1)空腹胰岛素水平；2)稳态模型评估(HOMA)。次要目标：与健康相关的生活质量和疲劳，脂肪组织：身体质量指数(BMI)，总脂肪质量(通过DEXA扫描测量)，腰围和臀围，矢状面厚度和躯干与周围脂肪的比率。血清胰岛素样生长因子；IGF-1；IGF-2；胰岛素样生长因子结合蛋白，IGFBP-1，IGFBP-3；瘦素。血清雌酮、总雌二醇、游离和生物可利用雌二醇、硫酸雌酮、总睾酮和游离睾酮、雄酮、脱氢表雄酮、脱氢表雄酮-S、性激素结合球蛋白。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of the preposed randomized trial are to examine in 50 postmenopausal women with breast cancer the effect of a Therapeutic Lifestyle Change intervention targeting weight loss incorporating a low-calorie diet and moderate intensity exercise program compared to a control condition on: Primary aims: Body weight change and insulin resistance change estimated by: 1) fasting insulin level and 2) Homeostasis Model Assessment (HOMA). Secondary aims: Health-related quality of life and fatigue, adipose tissue: Body Mass Index (BMI), total fat mass (measure via DEXA scan), waist and hip circumference, Sagittal thickness and the ratio of truncal versus peripheral fat. Serum Insulin-Like Growth Factors; IGF-1; IGF-2; Insulin-Like Growth Factor Binding Proteins, IGFBP-1, IGFBP-3; Leptin. Serum estrone, total estradiol, free and bioavailable estradiol, estrone sulphate, total and free testosterone, androsteindione, DHEA, DHEA-S, Sex Hormone Binding Globulin (SHBG).