EFFECTS OF TESTOSTERONE REPLACEMENT ON MUSCLE PERFORMANCE & PHYSICAL FUNC IN MEN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。随着年龄的增长，他们的肌肉往往会变得更小，更弱。肌肉无力使老年人难以走动进行日常生活活动，并增加了福尔斯和受伤的风险。男性血液中的雄性激素睾酮水平随着年龄的增长而下降。科学家们认为，睾丸激素水平较低可能会导致肌肉力量的丧失，以及老年男性的表现，而给予睾丸激素可能有助于改善肌肉力量，身体活动和整体幸福感。这项研究的主要目的是找出睾酮替代是否增加肌肉力量，性能和功能的老年男性（年龄65-85）与低肌肉质量（肌肉减少症）和低睾酮水平。另一个目的是找出这些男性睾丸激素的替代是否改善了生活质量。这是一项随机安慰剂对照试验，在这些男性中比较睾酮与安慰剂对这些结果的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As men grow older, their muscles tend to become smaller and weaker. Muscle weakness makes it difficult for older people to move around to do activities of daily living and increases the risk of falls and injuries. Blood levels of the male hormone testosterone in men decrease with advancing age. Scientists believe that lower levels of testosterone may contribute to both th eloss of muscle strength, and performance in older men and that giving testosterone may help to improve muscle strength, physical activity, and overall sense of well-being. The primary purpose of this study is to find out whether testosterone replacement increases muscle strength, performance, and function in older men (age 65-85) with low muscle mass (sarcopenia) and low testosterone levels. Another objective is to find out whether th ereplacement of testosterone in these men improves the quality of life. It is a randomized placebo controlled trial of the effect of testosterone vs. placebo on these outcomes, in these men.