TYPE 1 DIABETES GENETICS CONSORTIUM

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1型糖尿病遗传学联合会（T1DGC）将组织国际努力，确定决定个体患1型糖尿病风险的基因。1型糖尿病遗传学联盟的科学目标是：1。确定、研究和建立3000个“受影响的兄弟姐妹对”（ASP）家庭的可再生DNA来源，这些家庭至少有两个1型糖尿病兄弟姐妹，他们的父母，以及+/-不超过两个非糖尿病兄弟姐妹，用于研究可能与1型糖尿病相关的基因；2. 为科学界建立一个数据库，以促进对1型糖尿病易感基因的研究；3. 提供一个集中的DNA库，以便对1型糖尿病的遗传结构和功能进行有针对性的研究；4. 评估在1型糖尿病领域扩展研究成果以开发风险预测、预防和治疗方法的机会。为了实现这些目标，T1DGC将从全球五个研究确定的地理区域（亚太、欧洲、拉丁美洲、北美和英国）的兄弟姐妹和三人家庭收集信息和血液样本。本研究的最终目的是为基因鉴定提供临床和遗传资源，以达到必要的样本量和样本可用性。该联盟将建立一种机制，以确保科学家们将共同努力，更好地了解导致1型糖尿病风险的遗传因素。该联盟将更好地了解疾病机制，目的是改变1型糖尿病风险个体的这些机制和途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Type 1 Diabetes Genetics Consortium (T1DGC) will organize international efforts to identify genes that determine an individual's risk for type 1 diabetes. The scientific objectives of the Type 1 Diabetes Genetics Consortium are: 1. To ascertain, study and establish a renewable source of DNA on 3000 "affected sib-pair" (ASP) families with at least two type 1 diabetic siblings, their parents, and +/- up to two non-diabetic siblings for studies to map genes that may be associated with type 1 diabetes; 2. To create a database for the scientific community that would facilitate the search for type 1 diabetes susceptibility genes; 3. To provide a centralized DNA repository to allow targeted studies of genetic structure and function for type 1 diabetes; 4. To evaluate opportunities to extend the results of research to develop methods of risk prediction, prevention and therapy in the area of type 1 diabetes. To meet these objectives, the T1DGC will collect information and blood samples from sib-pair and trio families located in five study-defined geographic areas worldwide: Asia-Pacific, Europe, Latin America, North America, and the United Kingdom. The ultimate goal of this study is to provide the clinical and genetic resources to achieve the necessary sample size and sample availability for gene identification. The Consortium will establish a mechanism to ensure that scientists will work together toward a better understanding of the genetic factors that underlies risk for type 1 diabetes. The Consortium will gain a better understanding of disease mechanisms, with a purpose of altering these mechanisms and pathways in individuals at risk of type 1 diabetes.